Endotoxins, heat-stable lipopolysaccharides from Gram-negative bacteria, are potential
contaminants that can be introduced during manufacturing of pharmaceutical products …

Endotoxins, heat-stable lipopolysaccharides from Gram-negative bacteria, are potential
contaminants that can be introduced during manufacturing of pharmaceutical products …

Two new recombinant cascade reagents (rCRs), PyroSmart NextGen® and PYROSTAR TM
Neo, have recently become available for endotoxin testing of parenteral drugs in the …

Gram-negative bacterial endotoxins can cause pathophysiological effects such as high fever
when introduced into the bloodstream. Therefore, endotoxin testing is necessary when …

Endotoxin (lipopolysaccharide) testing of drugs is routinely required in pharmaceutical
industries. Suitable compendial assays are defined by national pharmacopoeias. At this …

Gram negative bacterial endotoxin is a biological pyrogen that causes fever when
introduced intravenously. The endotoxin, also known as lipopolysaccharide (LPS), is found …

The bacterial endotoxin test, which uses amebocyte lysate reagents of horseshoe crab
origin, is a sensitive, reproducible and simple assay to measure endotoxin concentration. To …

Pyrogens are substances (usually of biological origin) that cause fever after injection. The
best-studied pyrogen is lipopolysaccharide (LPS, also known as endotoxin), found in the …

The measurement of low levels of bacterial lipopolysaccharides (endotoxins) in protein
samples can be a challenge due to potential interference from the inherent properties of the …

Abstract The United States Pharmacopeia (USP), European Pharmacopeia (EP), and
Parenteral Drug Association (PDA) provide guidance on the validation of alternative …