Systematic design, generation, and application of synthetic datasets for flow cytometry

M Cheung, JJ Campbell, RJ Thomas, J Braybrook… - 2022 - repository.lboro.ac.uk
Application of synthetic datasets in training and validation of analysis tools have led to
improvements in many decision-making tasks in a range of domains from computer vision to …

Defining confidence in flow cytometry automated data analysis software platforms

M Cheung - 2022 - repository.lboro.ac.uk
The development of flow cytometry data analysis computational tools in recent yearshas the
potential to reduce the variation arising from manual gating and improve the quality of cell …

[HTML][HTML] Assessment of automated flow cytometry data analysis tools within cell and gene therapy manufacturing

M Cheung, JJ Campbell, RJ Thomas… - International Journal of …, 2022 - mdpi.com
Flow cytometry is widely used within the manufacturing of cell and gene therapies to
measure and characterise cells. Conventional manual data analysis relies heavily on …

SWIFT—scalable clustering for automated identification of rare cell populations in large, high‐dimensional flow cytometry datasets, Part 1: Algorithm design

I Naim, S Datta, J Rebhahn, JS Cavenaugh… - Cytometry Part …, 2014 - Wiley Online Library
We present a model‐based clustering method, SWIFT (Scalable Weighted Iterative Flow‐
clustering Technique), for digesting high‐dimensional large‐sized datasets obtained via …

Identifying cell populations in flow cytometry data using phenotypic signatures

MB Pouyan, M Nourani - IEEE/ACM Transactions on …, 2016 - ieeexplore.ieee.org
Single-cell flow cytometry is a technology that measures the expression of several cellular
markers simultaneously for a large number of cells. Identification of homogeneous cell …

flowLearn: fast and precise identification and quality checking of cell populations in flow cytometry

M Lux, RR Brinkman, C Chauve, A Laing… - …, 2018 - academic.oup.com
Motivation Identification of cell populations in flow cytometry is a critical part of the analysis
and lays the groundwork for many applications and research discovery. The current …

[HTML][HTML] Flow cytometry bioinformatics

K O'Neill, N Aghaeepour, J Špidlen… - PLoS computational …, 2013 - journals.plos.org
Flow cytometry bioinformatics is the application of bioinformatics to flow cytometry data,
which involves storing, retrieving, organizing, and analyzing flow cytometry data using …

A clustering hybrid method to identify cellular populations and their phenotypic signatures

MB Pouyan, V Jindal, M Nourani - 2015 IEEE Biomedical …, 2015 - ieeexplore.ieee.org
Flow cytometers have enabled researchers to measure 8 to 16 different cellular markers at
the single-cell level. Due to the encoded complexity in flow cytometry dataset across diverse …

Computational analysis of high-dimensional flow cytometric data for diagnosis and discovery

N Aghaeepour, R Brinkman - … Single Cell Analysis: Mass Cytometry, Multi …, 2013 - Springer
Recent technological advancements have enabled the flow cytometric measurement of tens
of parameters on millions of cells. Conventional manual data analysis and bioinformatics …

DAFi: A directed recursive data filtering and clustering approach for improving and interpreting data clustering identification of cell populations from polychromatic flow …

AJ Lee, I Chang, JG Burel… - Cytometry Part …, 2018 - Wiley Online Library
Computational methods for identification of cell populations from polychromatic flow
cytometry data are changing the paradigm of cytometry bioinformatics. Data clustering is the …