Glass prefilled syringes are increasingly becoming a container of choice for storing and
administering therapeutic protein products to patients. Tungsten leaching from a PFS is …

Particles isolated from a pre-filled syringe containing a protein-based solution were
identified as aggregated protein and tungsten. The origin of the tungsten was traced to the …

Leachable tungsten is associated with protein aggregation and precipitation in glass
prefilled syringes, and this may trigger immunogenicity concerns. Determining the level of …

Tungsten has been associated with protein aggregation in prefilled syringes (PFSs). This
study probed the relationship between PFSs, tungsten, visible particles, and protein …

Purpose Tungsten and tungsten oxide leachates found in glass pre-filled syringes were
identified to initiate protein precipitation and aggregation. Here, we tested the possibility of …

Tungsten microparticles may be introduced into some pre-filled syringes during the creation
of the needle hole. In turn, these microcontaminants may interact with protein therapeutics to …

Oral administration of sodium tungstate is an effective treatment for type 1 and 2 diabetes in
animal models; it does not incur significant side effects, and it may constitute an alternative …

Background: The aim of this paper was to validate an inductively coupled plasma-mass
spectrometry (ICP-MS) method to quantify tungsten in human plasma and to study its …

Purpose Following two cases of neutralizing antibodies to epoetin alfa in an investigational
clinical study, a small number of individual syringes of two drug product batches were found …

Electrospray mass spectrometry (ESMS) has been conducted on aqueous solutions of
isopolyoxotungstate systems. There is direct evidence that the desorption process in the …