The analysis and accurate quantitation of bioconjugations proves challenging in the case of
oligomeric proteins, especially when the size of the molecule or the nature of the conjugate …

Covalent attachment of synthetic polymers to proteins, known as protein–polymer
conjugation, is currently one of the main approaches for improving the physicochemical …

In addition to their use as therapeutics and because of their enhanced properties, PEGylated
proteins have potential application in fields such as bioprocessing. However, the use of …

PEGylated proteins are a rapidly growing class of biopharmaceutical products, but their
analytical characterization remains a formidable problem due to the extreme heterogeneity …

PEGylation stands out as a highly promising strategy for enhancing the stability of proteins
employed in clinical or industrial settings. Despite its widespread application, development …

The average number of methoxy poly (ethylene glycol)(mPEG) chains grafted to a protein–
also known as the degree of PEGylation–is a fundamental parameter for characterizing a …

PEGylation is a well-established and clinically proven half-life extension strategy for protein
delivery. Protein modification with amine-reactive poly (ethylene glycol)(PEG) generates …

BAX 855 (ADYNOVATE) is a PEGylated recombinant factor VIII (rFVIII) that showed
prolonged circulatory half-life compared to unmodified rFVIII in hemophilic patients. Here …

The high potential of peptides and proteins as therapeutic agents has not been fully
exploited because of their common shortcomings: the only exist for a short lifetime in the …

Protein conjugation is an effective way to impart different functionalities to the original
protein. Conjugation using a native protein (a protein that does not contain special unnatural …