Various kinds of treatments on the surface of the elastomeric components can have negative
impacts on the quality of protein therapeutics. We compared the effects of bare (non …

Currently, polymer-based prefillable syringes are being promoted to the pharmaceutical
market because they provide an increased break resistance relative to traditionally used …

Cells are known to respond differently when grown on materials of varying stiffness.
However, the mechanism by which a cell senses substrate stiffness is unknown. Lower …

Purpose To investigate the effect of plasticizers on the stability of protein formulations in the
solid state and to apply these results to a study of mechanisms of protein stabilization by …

Packaging of drugs in prefillable syringes offers considerable advantages over conventional
vials. Almost all major biotech molecules are available on the market today in prefilled …

Protein therapeutics are used to treat a wide range of diseases with significant benefits to
patients. Aggregation of the product is a significant challenge to the successful …

Protein products come into contact with many surfaces of differing wettability during
bioprocessing, formulation and delivery, but corresponding data for the adsorbed …

To improve liquid formulation stability, formulators employ various excipients designed to
stabilize protein drugs, including buffers, salts, sugars, and surfactants. One of the roles of …

Surfactants play an important role in stabilizing proteins in liquid formulations against
aggregate/particle formation during processing, handling, storage, and transportation. Only …

Prefilled syringes are widely used as a primary container for therapeutic proteins because
they are more convenient than glass vials. The stability of biologic molecules can be affected …