This study investigated the gas flow mechanism through microchannels in a flexible single-
use packaging system composed of multilayer plastic film. The relationship was studied …

This study investigated the liquid leakage mechanism through microchannels in a flexible
single-use packaging system composed of multilayer plastic film. Based on this study, a …

This concluding article of the publication series provides an overarching summary of all
study results presented in the three previous articles (–). Their interdependency in achieving …

It is often necessary to calculate a leak rate from the size of leak hole and vice versa for
testing of sealing packages such as foods, medicines and dangerous goods. These …

Container closure integrity testing (CCIT) is a critical step in ensuring package integrity and
providing feedback on package designs. In practical applications, CCIT methods, namely …

Characterization of the flow properties in microfluidic channels is important for designing
and building biomedical microdevices, many of which depend on precise fluid flow for their …

A direct test method using helium leak detection was developed to determine microbial
ingress in parenteral vial/rubber closure systems. The purpose of this study was to establish …

In principle, an aseptic package should protect against any type of microbe penetration. It
means that each microhole must be less than about 0.5 μm in diameter. In practice this …

Bright field transmitted light microscopy (BFTLM), differential interference contrast light
microscopy (DICLM), conventional scanning electron microscopy (SEM) and low‐vacuum …

For many years, glass, paper, and metal were the dominant primary materials for packaging
food, beverages, and medical products. However, over the past several years, high-barrier …