We illustrated the ability of electrospray mass spectrometry (MS) to identify extractables from
stoppers in biotech products. The advantages of using electrospray mass spectrometry (MS) …

With the rapid rise of therapeutic antibodies and antibody-drug conjugates, significant
investments have been made in developing workflows that utilize mass spectrometry to …

This work describes real examples of classes of drugs (drug candidates) whose quantitative
determination in biological matrices by high performance liquid chromatography with …

In this work, the usefulness of capillary electrophoresis–electrospray ionization time-of-flight–
mass spectrometry for the analysis of biopharmaceuticals was studied. Noncovalently bound …

Two polymeric excipients, typically used in enabling drug delivery approaches, are Gelucire
44/14 (a product of Gattefosse sa, St Priest, France) and polysorbate 80; these are known to …

RATIONALE Trace levels of bis (2, 4‐di‐tert‐butylphenyl) phosphate (BdtbPP) leaching from
single‐use bioreactors (SUBs) were recently found to be highly detrimental to mammalian …

A novel, solid phase extraction (SPE)-based sample preparation method was developed for
desorption electrospray ionization (DESI) mass spectrometry. Conventional SPE sample …

Biological fluids such as urine, saliva and whole blood were analyzed for contents of drugs
by a new combination of desorption electrospray ionizationmass spectrometry (DESI-MS) …

Organic extractables (substances extracted from materials used in pharmaceutical
packaging) are discovered, identified, and quantified via screening of extracts with analytical …

Applied mass spectrometric techniques can fundamentally be divided into those starting
from intact proteins (top down) and those starting from peptides derived by chemical or …