β-Propiolactone: Viral Inactivation in Vaccines and Plasma Products | PDA Journal of
Pharmaceutical Science and Technology Skip to main content Main menu Home Content Current …

Beta-propiolactone (ßPL) has been used extensively to inactivate viruses for both human
and veterinary vaccine production (1, 2). Human vaccines against influenza, and rabies …

Virus inactivation by cold treatment with β-propiolactone (BPL) was investigated in human
cyro poor plasma and purified IgG concentrates spiked with relevant human viruses or …

Beta-propiolactone (BPL) has been found to inactivate effectively all of the viruses against
which it has been tested. These include: Eastern and Western equine encephalitis (EEE and …

MATERIALS AND METHODS The effectiveness of BPL vapor was evaluated by determining
its activity against VEE when placed on cloth and paper patches. Preparation of virus seed …

Screening of 550 compounds for antiviral activity in plasma has revealed that most active
viricides can be classified in one of seven groups, based on chemical structure. Of the active …

Abstract. Intravenous immunoglobulins and serum protein solutions are manufactured from
human plasma pools of healthy, screened donors. A step-by-step validation of virus removal …

The efficacy of combined β-propiolactone/ultraviolet irradiation (βPL/UV) for inactivation of
hepatitis B virus in labile blood derivatives has been reviewed. The initial evaluations of …

Important factors to assure the safety of plasma-derived products manufactured on an
industrial scale are initial screening of the source material and validation of the …

In this paper, we will show that both antiviral compounds interact directly with, the viral
capsid, as demonstrated by the effect of arildone and 3-MQ on the thermal denaturation of …