A quantitative, sensitive, and reproducible kinetic turbidimetric adaptation of the Limulus
amebocyte lysate (LAL) assay was used to assess endotoxin adsorption/recovery from …

The inability to detect endotoxin using compendia methods is a potential safety concern for
patients due to the lack of endotoxin removal capabilities at the fill–finish stage in typical …

The data presented here show the kinetic turbidimetric LAL assay to be a highly quantitative
and effective method for determining endotoxin concentrations in products. The assay …

From January 1980 to October 1983, the Food and Drug Administration (FDA) examined
2526 samples, including 333 different drug products, by the limulus amebocyte lysate (LAL) …

Reduction of reference standard endotoxin activity was kinetically analyzed under low
endotoxin recovery conditions and was considered as an apparent first-order reaction …

Endotoxins are cell wall components of Gram-negative bacteria. A release of endotoxins into
the human blood stream results in an inflammation reaction that can lead to life-threatening …

The kinetics of destruction by dry heat of two typical endotoxins, Escherichia coli 055: B5 (E.
coli endotoxin) and Salmonella abortus equi (S. abortus equi endotoxin), were determined …

The inability to detect endotoxin added to undiluted drug samples has been called: Low
Endotoxin Recovery (LER). The phenomenon has caused concerns amongst drug …

PURPOSE: Endotoxins, also called lipopolysaccharides (LPS), are major contaminants
found in commercially available proteins or biologically active substances, which often …

A collaborative study, initiated under the auspices of the Health Industry Manufacturers
Association (HIMA), was designed to establish the relationship of Escherichia coli O55: B5 …