Some users have been hesitant to take on the validation of alternative methods. However,
recombinant factor C (rFC) tests are so highly analogous to the horseshoe crab-sourced …

Some users have been hesitant to take on the validation of alternative methods. However,
recombinant factor C (rFC) tests are so highly analogous to the horseshoe crab-sourced …

Gram-negative bacterial endotoxins can cause pathophysiological effects such as high fever
when introduced into the bloodstream. Therefore, endotoxin testing is necessary when …

If we want to scientifically understand the dynamics of LAL and rFC in terms of equivalency,
then we must be able to sort out some conflicting data. Five broad claims have been made …

Activated protein C (APC) acts as an “on demand” anticoagulant, reducing thrombin
formation. Reduced plasma levels of APC or protein C (PC) are associated with an …

Dr. Rifai and coauthors seem to have misunderstood the guidance proffered by the US Food
and Drug Administration (FDA) 1 and the laboratory safety tip addressing the issue of …

To determine the performance and frequency of protein C reagents currently used by clinical
laboratories, we analyzed North American Specialized Coagulation Laboratory Association …

Background and aims Protein C is a plasma protein, and its active form regulates blood
coagulation. The recommended unit of protein C activity is IU/mL; however, some …

Several articles in recent issues of Clinical Chemistry have made reference to the Dade
Behring N High Sensitivity CRP (hs-CRP) assay and have indicated that it has been …

There is wide variability of factor activity level resultsdepending upon the assay selected to
perform the task (ie one stage assays vs. chromogenic assays). In certain scenarios, a …