Formulation optimization of long-acting depot injection of aripiprazole by using D-optimal mixture design

T Nahata, TR Saini - PDA Journal of Pharmaceutical Science and …, 2009 - journal.pda.org
Non-adherence to medication specifications is a major cause for poor outcomes in the
therapy of schizophrenia. In situ implantable preparation of aripiprazole, an atypical …

D-optimal designing and optimization of long acting microsphere-based injectable formulation of aripiprazole

T Nahata, TR Saini - Drug development and industrial pharmacy, 2008 - Taylor & Francis
This work was aimed to design and optimize a long acting microsphere-based injectable
formulation of aripiprazole by using D-optimal experimental design methodology …

Development and Optimization of Aripiprazole ODT by using box-Behnken Design

AK Chettupalli, PA Rao, M Kuchukuntla… - Research Journal of …, 2020 - indianjournals.com
The main objective of the study is to develop and optimize the potential variables which
influence aripiprazole oral disintegration tablets (ODTs) formulation. Aripiprazole ODTs were …

Optimization of injectable PLGA in-situ forming implants of anti-psychotic risperidone via Box-Behnken Design

TM Ibrahim, NA El-Megrab, HM El-Nahas - Journal of Drug Delivery …, 2020 - Elsevier
The current study aims to develop in-situ forming implants (ISFI) of anti-psychotic risperidone
to customize schizophrenia therapy. Non-adherence to treatment is the most prevalent …

Aripiprazole Lauroxil NanoCrystal® Dispersion Technology (Aristada Initio®)

MJ Ehret, E Davis, SE Luttrell… - … schizophrenia & related …, 2018 - meridian.allenpress.com
Nonadherence to antipsychotic medications for the treatment of schizophrenia is a widely
recognized concern, leading to poorer clinical outcomes and higher treatment costs. Long …

Enhancement of encapsulation efficiency of nanoemulsion-containing aripiprazole for the treatment of schizophrenia using mixture experimental design

HR Fard Masoumi, M Basri… - International journal …, 2015 - Taylor & Francis
Aripiprazole is considered as a third-generation antipsychotic drug with excellent
therapeutic efficacy in controlling schizophrenia symptoms and was the first atypical anti …

[HTML][HTML] Population pharmacokinetic analysis and model-based simulations of aripiprazole for a 1-day initiation regimen for the long-acting antipsychotic aripiprazole …

ML Hard, AY Wehr, BM Sadler, RJ Mills… - European journal of …, 2018 - Springer
Abstract Background and Objectives Aripiprazole lauroxil (AL), a long-acting injectable
antipsychotic for the treatment of schizophrenia, requires 21 days of oral aripiprazole …

Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles: In vitro and in vivo evaluation

V Piazzini, E Landucci, M Urru, A Chiarugi… - International Journal of …, 2020 - Elsevier
Aripiprazole (ARP) is an antipsychotic drug approved for the treatment of schizophrenia. It is
poorly water-soluble and undergoes extensive hepatic metabolism and P-gp efflux, which …

[PDF][PDF] Solubility enhancement of aripiprazole by solid-self emulsifying drug delivery systems

A Chennuri, D Prasanthi - International Journal of Pharmaceutical …, 2018 - researchgate.net
Self-emulsifying drug delivery systems are a promising approach for the formulation of drug
compounds with poor aqueous solubility. The main objective of this work was to formulate …

[HTML][HTML] Enhanced Solubility and Stability of Aripiprazole in Binary and Ternary Inclusion Complexes Using Hydroxy Propyl Beta Cyclodextrin (HPβCD) and L-Arginine

S Awais, N Farooq, SA Muhammad, HA El-Serehy… - Molecules, 2023 - mdpi.com
The low water solubility of an active pharmaceutical ingredient (aripiprazole) is one of the
most critical challenges in pharmaceutical research and development. This antipsychotic …