The solubilization of zomepirac, a non-narcotic analgesic, by tromethamine and related
bases is described. Solubilization is affected by a micellar mechanism as demonstrated by …

In an in vitro study the release rates of zomepirac acid (I) and zomepirac sodium dihydrate
(II) from suspensions in liquid paraffin towards an aqueous phase were determined. When …

The solution properties of several analgesics including dextropropoxyphene hydrochloride,
methadone hydrochloride, dextromoramide acid tartrate and dipipanone hydrochloride have …

The plasma protein binding of zomepirac, a new nonnarcotic analgesic, was studied using
equilibrium dialysis. Experiments were performed using human plasma and plasma from …

The pharmacokinetics and renal handling of zomepirac, a new analgesic agent, were
studied in rhesus monkeys. Single oral 5, 10 and 40 mg/kg doses were administered to …

The solubilisation of temazepam by hydrotropic complexation has been investigated.
Sodium salicyate and nicotinamide were used as hydrotropes. The former allowed …

Zomepirac sodium, sodium 5-(4chlorobenzoyl)-1, 4-dimethyl-lH-pyrrole-2-acetate dihydrate,
is an orally active, non-narcotic analgesic agent [l-3]. Prior publications from these …

A sensitive, specific and precise high-pressure liquid-chromatographic method for the
determination of the analgesic agent, zomepirac, in plasma samples is described. The …

The solubility of diazepam and prazepam in aqueous polyoxyethylen‐10‐dodecanol,
polyoxyethylen‐23‐dodecanol and polyoxyethylen‐20‐hexadecanol, has been determined …

Ketoprofen (1) an analgesic, antipyretic and anti-inflammatory agent, is practically insoluble
in water. An increase in the aqueous solubility of 1 was attempted by various cosolvents …