Improved Parenteral Formulations for Traditional Antiepileptics | PDA Journal of Pharmaceutical
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When designing a formulation for a therapeutic agent, manufacturers have to consider
divergent factors such as bio-availability, acceptability to the patient, shelf life and market …

In the past years, the extended-release antiepileptic drug formulations have been developed
and then approved for the treatment of many types of epilepsy. Among these extended …

The advent of numerous new treatment options in epilepsy therapy over the last decade is
enabling a more flexible and individualised approach to patients with seizures. For some …

Comparative studies are needed to elucidate the specific weaknesses and strengths of each
of the new antiepileptic drugs compared with the older ones. Most clinical trials do not help …

This review analyses the concept of extended-release (ER) formulations in epilepsy and
evaluates ER formulations of carbamazepine, valproic acid and a modified-release (MR) …

Extended-release products are designed to prolong the absorption of drugs with short half-
lives, thereby allowing longer dosing intervals while minimizing fluctuations in serum drug …

Abstract “Add-on” parallel designs have frequently been used to demonstrate efficacy for a
new antiepileptic drug in refractory patients. It might he very difficult to show effects in this …

Objective: In the treatment of epilepsy, as in all areas of drug therapy, generic formulations
are becoming more important as pressure to reduce drug costs increases. In clinical …

ABSTRACT Introduction: Extended-release (ER) preparations are either available or have
been tested for several antiepileptic drugs (AEDs). Indeed, they may be helpful in improving …