Evaluation of microparticles containing doxorubicin suitable for aerosol delivery to the lungs

Y Tian, ME Klegerman, AJ Hickey - PDA Journal of Pharmaceutical …, 2004 - journal.pda.org
The efficacy of microparticulate systems containing anticancer agents may be assessed in
vitro prior to evaluation of the effects of targeted and controlled drug release on tumor …

Pharmacokinetics and tissue distribution of spray-dried carboplatin microspheres: lung targeting via intravenous route

S Harsha, M Al-Khars, M Al-Hassan, NP Kumar… - Archives of pharmacal …, 2014 - Springer
For cancer therapy, microspheres can be used to increase effectiveness while decreasing
side effects of treatments. We prepared gelatin microspheres containing carboplatin …

Microparticulate drug delivery systems as an adjunct to cancer treatment

DJ KERR - Cancer drug delivery, 1987 - liebertpub.com
In an attempt to improve the therapeutic ratio of cytotoxic drugs, which have steep dose-
response curves, microparticulate drug delivery systems (MDDS) have been designed for …

Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles

S Azarmi, X Tao, H Chen, Z Wang, WH Finlay… - International journal of …, 2006 - Elsevier
Regional drug delivery via dry powder inhalers offers many advantages in the management
of pharmaceutical compounds for the prevention and treatment of respiratory diseases. In …

Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model

WH Roa, S Azarmi, MHDK Al-Hallak, WH Finlay… - Journal of controlled …, 2011 - Elsevier
Doxorubicin-loaded nanoparticles (NPs) were incorporated into inhalable effervescent and
non-effervescent carrier particles using a spray–freeze drying technique. The prepared …

Spray-dried doxorubicin-albumin microparticulate systems for treatment of multidrug resistant melanomas

AK Jones, NK Bejugam, H Nettey, R Addo… - Journal of Drug …, 2011 - Taylor & Francis
As multidrug resistance continues to be a problem in cancer treatment, controlled release
delivery systems, such as microspheres, may aid to give a slower release of anticancer …

Clinical uses of microcapsules and microspheres

K Juni, M Nakano - … and Nanoparticles in Medicine and Pharmacy, 2020 - taylorfrancis.com
Microcapsules may function as carriers of drugs to desired regions in the body and as
depots from which drugs are released in a controlled pattern. In oral dosage forms, the …

Sustained release chemotherapeutic microspheres provide superior efficacy over systemic therapy and local bolus infusions

DF Emerich, P Snodgrass, D Lafreniere, RL Dean… - Pharmaceutical …, 2002 - Springer
Purpose. The present studies evaluated the ability of injectable, biodegradable
microspheres releasing carboplatin, doxorubicin, or 5-fluorouracil to suppress the growth of …

Microspheres-a new drug delivery system: A review

VB Metkari, LV Kulkarni, PS Patil… - Journal of Current …, 2014 - search.proquest.com
Microspheres are normally free flowing powders consisting of proteins or synthetic polymers
which are biodegradable in nature and preferably having a particle size less than 200... m …

[PDF][PDF] Micro-and nano-particulate drug delivery systems for cancer treatment

JL Arias - OF PHARMACOLOGY RESEARCH (2 VOLUME SET), 2009 - academia.edu
Actual chemotherapy relies on the premise that rapidly proliferating cancer cells are more
likely to be killed by a cytotoxic agent. However, anticancer drugs have little or no specificity …