Abstract
The Limited Spearman-Karber Procedure (LSKP) and Stumbo Murphy and Cochran Procedure (SMCP) are procedures to determine D-value in the Most Probable Number method (MPN). International Organization for Standardization (ISO)/Technical Committee 198/Working Group 4 contributing for the preparation of documents on biological indicator has adopted only LSKP in MPN. SMCP has been rejected due to the reason of inaccuracy without any scientific proof. Therefore, in order to confirm whether this is scientifically correct or not, Japanese delegates decide to compare both methods in simulation and experimental procedures using biological indicator and biological indicator evaluator resistometer. The result indicated that SMCP with some restrictions was not always inferior to LSKP and gave identical results.
- Received September 27, 1994.
- Accepted March 3, 1995.
- Copyright © Parenteral Drug Association. All rights reserved.
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