Abstract
Ethylene oxide gas (EO) is shown to affect Bacillus subtilis spore outgrowth kinetics without detectably affecting germination kinetics. Outgrowth of EOtreated spores is delayed up to 18 hr. The delay is not the result of an alteration in the exponential growth rate of the resulting vegetative cell population. Post-process B. subtilis biological indicators (BI’s) utilizing paper carriers, retain detectable residual EO levels for at least 48 hr. The data indicate that these levels are absorbed to the spores. Consequently. small EO residual levels potentially have significant biological consequences. As a result of the evidence of EO spore injury and retained EO residual levels, it is important that EO, BI recovery systems must be designed with meticulous care. Specific considerations for the design of a BI recovery system are outlined.
- Received November 26, 1979.
- Accepted January 21, 1980.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.
Log in using your username and password
Log in through your institution
Purchase access
patientACCESS
In This Issue
Jump to section
Related Articles
Cited By...
- No citing articles found.