Abstract
At the radiopharmacy Section of the Nuclear Medicine Department of the Instituto Nacional de Nutricion, in Mexico City, all of the short half life radiopharmaceuticals are prepared and administered to the patients who are referred for organ scanning. The routine quality control of all the preparations includes radiochemical purity, labeling efficiency and sterility of the products. For a trial period the Limulus amebocyte lysate test has been used for pyrogen detection in the 99mTc-radiopharmaceuticals. A micro method was used in 204 radiopharmaceuticals including pertechnetate, sulfur colloid, pyrophosphates, pyridoxylidenglutamate, human serum albumin, and human serum albumin macroagregates. Parenteral fluids used for the kit preparation were also tested. The gel formation in the 6 pyrogenic radiopharmaceuticals (2.94%) was slow in appearing (30 min). In this trial run our results have been so promising that we have decided to make the micro Limulus amebocyte lysate test a part of our quality control routine.
- Received January 31, 1980.
- Accepted March 19, 1980.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.