Abstract
ABSTRACT: Microbiological control in clean piping systems is limited by transport processes that distribute the disinfecting medium. The critical locations where transport resistance can be expected are the piping dead legs. Transport in dead legs was analyzed theoretically for two common disinfection methods: thermal; and ozone treatment. Established guidelines for clean piping design should not be universally applied. Specific guidelines for these different technologies are proposed. By differentiating between permanent and temporary dead legs, ozonated systems can be designed to be at least as reliable as thermal systems. Scale-up of thermal systems should include increasing the circulating velocity of the loop.
- Received April 14, 1993.
- Accepted September 1, 1993.
- Copyright © Journal of Pharmaceutical Science and Technology(JPST). All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.