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Research ArticleTECHNOLOGY/APPLICATIONS

Selection of Biological Indicator for Validating Microwave Heating Sterilization

Koichi Sasaki, Yumi Mori, Washiro Honda and Yasuo Miyake
PDA Journal of Pharmaceutical Science and Technology March 1998, 52 (2) 60-65;
Koichi Sasaki
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Yumi Mori
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Washiro Honda
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Yasuo Miyake
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Abstract

For the purpose of selecting an appropriate biological indicator for evaluation of the effects of microwave heating sterilization, we examined aerobic bacterial spores to determine whether microwaves have non-thermal sterilization effects. After microwave irradiation on dry bacterial spores (three species), none of the bacterial spores were killed. The survival rate of the spores after microwave irradiation of spore suspensions (twelve species) was compared with that after heating by a conventional method. The order of heat resistance in the bacterial species was similar between the two heating methods. Bacillusstearothermophilus spores were the most heat-resistant. These results suggest that microwaves have no non-thermal sterilization effects on bacterial spores, the specific resistant spores to microwave heating, and microwave heating sterilization can be evaluated in the same way as for conventional heating sterilization. As a biological indicator for evaluation of overkill sterilization, B. stearothermophilus spores may be appropriate for microwave heating sterilization as well as steam sterilization.

Footnotes

    • Received May 22, 1997.
    • Accepted October 8, 1997.
  • Copyright © Parenteral Drug Association. All rights reserved.

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PDA Journal of Pharmaceutical Science and Technology
Vol. 52, Issue 2
March/April 1998
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Selection of Biological Indicator for Validating Microwave Heating Sterilization
Koichi Sasaki, Yumi Mori, Washiro Honda, Yasuo Miyake
PDA Journal of Pharmaceutical Science and Technology Mar 1998, 52 (2) 60-65;

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Selection of Biological Indicator for Validating Microwave Heating Sterilization
Koichi Sasaki, Yumi Mori, Washiro Honda, Yasuo Miyake
PDA Journal of Pharmaceutical Science and Technology Mar 1998, 52 (2) 60-65;
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More in this TOC Section

  • Evaluation of Steam Sterilization Processes: Comparing Calculations Using Temperature Data and Biointegrator Reduction Data and Calculation of Theoretical Temperature Difference
  • Optimization of the Drug Solution Preparation Process for a Production-Scale Crossflow Ultrafiltration System
  • Bacterial Adhesion: Considerations Within A Risk-Based Approach To Cleaning Validation
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