Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleTECHNOLOGY/APPLICATION

Air Sampling System for Use in Monitoring Viable and Non-viable Particulate Air Quality Under Dynamic Operating Conditions of Blow/Fill/Seal Processing

Steve Probert, Colin S. Sinclair and Alan Tallentire
PDA Journal of Pharmaceutical Science and Technology September 2002, 56 (5) 267-276;
Steve Probert
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Colin S. Sinclair
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan Tallentire
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tallent@adl.u-net.com
  • Article
  • References
  • Info & Metrics
  • PDF
Loading

Abstract

An Air Sampling Link (ASL), employed in conjunction with an Air Sampling Device (ASD) or a laser particle counter, has been developed for sampling flowing air for viable and non-viable particulate analyses. Typically, the ASL could be used to sample filtered air supplied to an air shower of a Blow/Fill/Seal machine operating in the dynamic state. The ASL allows sample volumes of air to be taken from flowing air without significant loss from the sample flow of airborne particles possessing aerodynamic sizes relevant to those found in practice. The link has no moving parts, is steam sterilizable in-situ, and allows for the taking of continuous samples of air without the need for intervention into the ‘critical zone’of the filling machine. This article describes (i) the design criteria for the ASL and the ASD, (ii) the rationale underlying the concept of the ASL design, (iii) the collection performance of the ASL against that of a conventional sampling arrangement, and (iv) a functionality assessment of the ASL-based sampling system installed on a Rommelag style 305 B/F/S machine over a seven week period.

  • Air sampling
  • air shower
  • critical fill zone
  • Blow/Fill/Seal
  • B/F/S

Footnotes

  • Copyright © Parenteral Drug Association. All rights reserved.

PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.  

If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing. 

Full issue PDFs are for PDA members only.

Note to pda.org users

The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.

Log in using your username and password

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

patientACCESS

patientACCESS - Patients desiring access to articles

Full issue PDFs are for PDA members only. You can join PDA at www.pda.org. 

PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology
Vol. 56, Issue 5
September/October 2002
  • Table of Contents
  • Index by Author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Air Sampling System for Use in Monitoring Viable and Non-viable Particulate Air Quality Under Dynamic Operating Conditions of Blow/Fill/Seal Processing
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
11 + 2 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Air Sampling System for Use in Monitoring Viable and Non-viable Particulate Air Quality Under Dynamic Operating Conditions of Blow/Fill/Seal Processing
Steve Probert, Colin S. Sinclair, Alan Tallentire
PDA Journal of Pharmaceutical Science and Technology Sep 2002, 56 (5) 267-276;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Air Sampling System for Use in Monitoring Viable and Non-viable Particulate Air Quality Under Dynamic Operating Conditions of Blow/Fill/Seal Processing
Steve Probert, Colin S. Sinclair, Alan Tallentire
PDA Journal of Pharmaceutical Science and Technology Sep 2002, 56 (5) 267-276;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Mechanical Container Closure Integrity Test: A Method for Cartridge Systems
  • A Container Closure Integrity Test Method for Vials Stored at Cryogenic Conditions Using Headspace Oxygen Analysis
  • Best Practices for Microbial Challenge In-Use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations
Show more Technology/Application

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire