Abstract
This work investigated the potential of solid lipid nanoparticles (SLNs) to improve oral bioavailablity and tissue uptake of a poorly soluble drug, α-Asarone. Ultrasonic homogenization method was employed to prepare α-Asarone-loaded SLNs (α-Asarone-SLNs). Particle size and distribution, pH, viscosity, drug incorporation and zeta potential of the SLNs were investigated. Pharmacokinetic study of oral administration to male rats at 10 mg/Kg suggested that the relative bioavailability of α-Asarone was significantly improved in α-Asarone-SLN group compared to α-Asarone solution group. Comparison of α-Asarone-SLN to α-Asarone control solution for α-Asarone concentrations in rat tissue showed an increased uptake of α-Asarone in brain and lung for the ARE-SLN group. These results indicate that α-Asarone-SLNs significantly enhance the absorption and tissue distribution of α-Asarone. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs.
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