Research ArticleRESEARCH

The Oxidation of Methionine-54 of Epoetinum alfa Does Not Affect Molecular Structure or Stability, but Does Decrease Biological Activity

Steven R. LaBrenz, Melissa A. Calmann, George A. Heavner and Glen Tolman
PDA Journal of Pharmaceutical Science and Technology May 2008, 62 (3) 211-223;

Article Information

vol. 62 no. 3 211-223
PubMed 
18661870
Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online May 1, 2008.
Copyright & Usage 
Copyright © Parenteral Drug Association. All rights reserved.

Author Information

  1. Steven R. LaBrenz1,
  2. Melissa A. Calmann1,
  3. George A. Heavner2 and
  4. Glen Tolman1
  1. 1Pharmaceutical Technology, Global Biologics Supply Chain, LLC, 200 Great Valley Parkway, Malvern, PA 19355
  2. 2Centocor Research and Development, Technology Discovery Research, 145 King of Prussia Road, Radnor, PA 19087
  1. Corresponding author: Steven LaBrenz,
    Principal Process Scientist, Global Biologics Supply Chain, LLC, 200 Great Valley Parkway, Mail Stop M-7-2, Malvern, PA 19355
    , Tel: 610-407-8840, Fax: 610-651-7261, Email: slabrenz{at}cntus.jnj.com

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The Oxidation of Methionine-54 of Epoetinum alfa Does Not Affect Molecular Structure or Stability, but Does Decrease Biological Activity
Steven R. LaBrenz, Melissa A. Calmann, George A. Heavner, Glen Tolman
PDA Journal of Pharmaceutical Science and Technology May 2008, 62 (3) 211-223;
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