Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleRESEARCH

Effect of High Calcium and Phosphate Concentrations on the Physicochemical Properties of Two Lipid Emulsions Used as Total Parenteral Nutrition for Neonates

Sonia Driss Chaieb, Jean-Claude Chaumeil, Sami Jebnoun, Naima Khrouf, Abderrazek Hedhili and Souad Sfar
PDA Journal of Pharmaceutical Science and Technology January 2009, 63 (1) 27-41;
Sonia Driss Chaieb
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: sonia.chaieb@rns.tn chaieb_sonia@yahoo.fr
Jean-Claude Chaumeil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sami Jebnoun
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naima Khrouf
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abderrazek Hedhili
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Souad Sfar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Rigo J.,
    2. Senterre J.
    Nutritional needs of premature infants: current issues. J. Pediatrics 2006, 149 ( 5), S80– S88.
    OpenUrlCrossRefWeb of Science
  2. 2.↵
    1. Hay W. W.,
    2. Lucas A.,
    3. Heird W. C.,
    4. Ziegler E.,
    5. Levin E.,
    6. Grave G. D.,
    7. Catz C. S.,
    8. Yaffe S.
    Workshop summary: nutrition of extremely low birth weight infant. Pediatrics 1999, 104 ( 6), 1360– 1368.
    OpenUrlFREE Full Text
  3. 3.↵
    1. Chaumeil J. C.,
    2. Brossard D.
    Stabilité des émulsions lipidiques utilisées en nutrition parentérale. Nutr. Clin. Metab. 1993, 7 ( 1), 55– 64.
    OpenUrl
  4. 4.↵
    1. Driscoll D. F.
    Physicochemical assessment of total nutrient admixture stability and safety: quantifying the risk. Nutrition 1997, 13 ( 2), 166– 167.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Lee M. D.,
    2. Yoon J. E.,
    3. Kim S. I.,
    4. Kim I. C.
    Stability of total nutrient admixtures in reference to ambient temperatures. Nutrition 2003, 19 ( 10), 886– 890.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Driscoll D. F.
    Lipid injectable emulsions: 2006. Nutr. Clin. Pract. 2006, 21 ( 4), 381– 386.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Driscoll D. F.
    Lipid injectable emulsions: Pharmacopeial and safety issues. Pharm. Res. 2006, 23 ( 9), 1959– 1969.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Washington C.
    Stability of lipid emulsions for drug delivery. Adv. Drug Delivery Rev. 1996, 20 ( 2-3), 131– 145.
    OpenUrlCrossRef
  9. 9.↵
    1. Parry V. A.,
    2. Harrie K. R.,
    3. McIntosh-Lowe N. L.
    Effect of various nutrient ratios on the emulsion stability of total nutrient admixtures. Am. J. Hosp. Pharm. 1986, 43 ( 12), 3017– 3022.
    OpenUrlAbstract
  10. 10.↵
    1. Balogh J.,
    2. Bubenik J.,
    3. Dredan J.,
    4. Csempesz F.,
    5. Kiss D.,
    6. Zelko R.
    The effect of structured triglycerides on the kinetic stability of total nutrient admixtures. J. Pharm. Pharm. Sci. 2005, 8 ( 3), 552– 557.
    OpenUrlPubMed
  11. 11.↵
    1. Hill S. E.,
    2. Heldman L. S.,
    3. Goo E. D. H.,
    4. Whippo P. E.,
    5. Perkinson J. C.
    Fatal microvascular pulmonary emboli from precipitation of total nutrient admixture solution. J. Parenteral Enteral Nutrition 1996, 20 ( 1), 81– 87.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Calder P. C.
    Parenteral Lipid Emulsions and Immune Function. Clinoleic Satellite Symposium, 20th Annual Meeting of European Society of Enteral and Parenteral Nutrition (E. S. P. E. N.), Nice, France, 1998.
  13. 13.↵
    1. Balogh J.,
    2. Kiss D.,
    3. Dredan J.,
    4. Puskas I.,
    5. Csempesz F.,
    6. Zelko R.
    Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions. AAPS PharmSciTech 2006, 7 ( 4) Article 98.
  14. 14.↵
    1. Bettner F. S.,
    2. Stennett D. J.
    Effects of pH, temperature, concentration and time on particle counts in lipid-containing total parenteral nutrition admixtures,” J. Parenteral Enteral Nutrition 1986, 10 ( 4), 375– 380.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Driscoll D. F.,
    2. Nehne J.,
    3. Peterss H.,
    4. Klutsch K.,
    5. Bistrian B. R.,
    6. Niemann W.
    Physicochemical stability of intravenous lipid emulsions as all-in-one admixtures intended for the very young,” Clin. Nutr. 2003, 22 ( 5), 489– 495.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Black C. D.,
    2. Popovich N. G.
    A study of intravenous emulsion compatibility effects of dextrose, amino acids and selected electrolytes,” Drug Intell. Clin. Pharm. 1981, 15 ( 3), 184– 193.
    OpenUrlPubMed
  17. 17.↵
    1. Barnett M. I.,
    2. Cosslett A. G.,
    3. Duffield J. R.,
    4. Evans D. A.,
    5. Hall S. B.,
    6. Williams D. R.
    Parenteral nutrition: Pharmaceutical problems of compatibility and stability. Drug Safety 1990, 5 ( Suppl. 1), 101– 106.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Washington C.,
    2. Ferguson J. A.,
    3. Irwin S. E.
    Computational prediction of the stability of lipid emulsions in total nutrient admixtures. J. Pharm. Sci. 1993, 82 ( 8), 808– 812.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Driscoll D. F.,
    2. Etzler F.,
    3. Barber T. A.,
    4. Nehne J.,
    5. Niemann W.,
    6. Bistrian B. R.
    Physicochemical stability assessments of lipid emulsions: Light obscuration versus laser diffraction. Int. J. Pharm. 2001, 219 ( 1-2), 21– 37.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Driscoll D. F.,
    2. Giampietro K.,
    3. Wichelhaus D.,
    4. Peterss H.,
    5. Nehne J.,
    6. Niemann W.,
    7. Bistrian B. R.
    Physicochemical stability assessments of lipid emulsions of varying oil composition,” Clinical Nutrition 2001, 20 ( 2), 151– 157.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Driscoll D. F.,
    2. Newton D. W.,
    3. Bistrian B. R.
    Precipitation of calcium phosphate from parenteral nutrition fluids. Am. J. Hosp. Pharm. 1994, 51, 2834– 2836.
    OpenUrlPubMedWeb of Science
  22. 22.↵
    1. Allwood M. C.,
    2. Kearney J. M. C.
    Compatibility and stability of additives in parenteral nutrition admixtures. Nutrition 1998, 14 ( 9), 697– 706.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Raupp P.,
    2. Kries R. V.,
    3. Pfahl H. G.,
    4. Manz F.
    Glycero- vs glucose phosphate in parenteral nutrition of premature infants: a comparative in vitro evaluation of calcium phosphorus compatibility. J. Parenteral Enteral Nutrition 1991, 15 ( 4), 469– 473.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Prinzivalli M.,
    2. Ceccarelli S.
    Sodium d-fructose-1,6-diphosphate vs sodium monohydrogen phosphate in total parenteral nutrition: a comparative in vitro assessment of calcium phosphate compatibility. J. Parenteral Enteral Nutrition 1999, 23 ( 6), 326– 332.
    OpenUrlAbstract/FREE Full Text
  25. 25.↵
    1. Chaieb D. S.,
    2. Chaumeil J. C.,
    3. Jebnoun S.,
    4. Khrouf N.,
    5. Hedhili A.,
    6. Sfar S.
    Calcium and phosphate compatibility and stability studies in different neonatal parenteral nutrition mixtures. Eur. J. Hosp. Pharm.—Sci. 2006, 2, 35– 40. Full text at www.ejhp.org.
    OpenUrl
  26. 26.↵
    1. Gellis C.,
    2. Arvouet A.,
    3. Sautou-Miranda V.,
    4. Exbrayat A.,
    5. Tramier V.,
    6. Corny-Peccoux S.,
    7. Chopineau J.
    Etude préliminaire de hautes concentrations calciques et phosphatées en mélanges ternaires pédiatriques de nutrition parentérale. Nutr. Clin. Metabol. 2000, 14 ( 1), 34– 46.
    OpenUrl
  27. 27.↵
    1. Rubin M.,
    2. Bilik R.,
    3. Aserin A.,
    4. Ziv Y.,
    5. Sinai Y.,
    6. Dintsman M.
    Catheter obstruction: Analysis of filter content of total nutrient admixture. J. Parenteral Enteral Nutrition 1989, 13 ( 6), 641– 643.
    OpenUrlAbstract/FREE Full Text
  28. 28.↵
    1. Ball P. A.
    Methods of assessing stability of parenteral nutrition regimens. Curr. Opin. Clin. Nutr. Metab. Care 2001, 4 ( 5), 345– 349.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Lewis J. S.
    Justification for use of 1.2 micron end–line filters on total nutrition admixtures. Hosp. Pharm. 1993, 28, 656.
    OpenUrl
  30. 30.↵
    1. Ball P. A.,
    2. Bethune K.,
    3. Fox J.,
    4. Ledger R.,
    5. Barnett M.
    Particulate contamination in parenteral nutrition solutions: Still a cause for concern? Nutrition 2001, 17 ( 11-12), 926– 929.
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology
Vol. 63, Issue 1
January/February 2009
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effect of High Calcium and Phosphate Concentrations on the Physicochemical Properties of Two Lipid Emulsions Used as Total Parenteral Nutrition for Neonates
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
4 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Effect of High Calcium and Phosphate Concentrations on the Physicochemical Properties of Two Lipid Emulsions Used as Total Parenteral Nutrition for Neonates
Sonia Driss Chaieb, Jean-Claude Chaumeil, Sami Jebnoun, Naima Khrouf, Abderrazek Hedhili, Souad Sfar
PDA Journal of Pharmaceutical Science and Technology Jan 2009, 63 (1) 27-41;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Effect of High Calcium and Phosphate Concentrations on the Physicochemical Properties of Two Lipid Emulsions Used as Total Parenteral Nutrition for Neonates
Sonia Driss Chaieb, Jean-Claude Chaumeil, Sami Jebnoun, Naima Khrouf, Abderrazek Hedhili, Souad Sfar
PDA Journal of Pharmaceutical Science and Technology Jan 2009, 63 (1) 27-41;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Quantitative and Qualitative Evaluation of Microorganism Profile Identified in Bioburden Analysis in a Biopharmaceutical Facility in Brazil: Criteria for Classification and Management of Results
  • Evaluation of Extreme Depyrogenation Conditions on the Surface Hydrolytic Resistance of Glass Containers for Pharmaceutical Use
  • A Holistic Approach for Filling Volume Variability Evaluation and Control with Statistical Tool
Show more Research

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire