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Research ArticleRESEARCH

Preparation, Characterization, and In Vivo Pharmacodynamic Evaluation of Parenteral Diclofenac Submicron Lipid Emulsions

Endabetla Varshika, Kandadi Prabhakar and Veerabrahma Kishan
PDA Journal of Pharmaceutical Science and Technology September 2009, 63 (5) 380-389;
Endabetla Varshika
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Kandadi Prabhakar
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Veerabrahma Kishan
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  • For correspondence: vbkishan@yahoo.com
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References

  1. ↵
    1. Lundberg B.
    Preparation of drug-carrier emulsions stabilized with phosphatidylcholine-surfactant mixtures. J. Pharm. Sci. 1994, 83 (1),72–75.
    OpenUrlPubMed
  2. ↵
    1. Lundberg B.
    A submicron lipid emulsion coated with amphipathic polyethylene glycol for parenteral administration of Paclitaxel (Taxol). J. Pharm. Pharmacol. 1997, 49 (1),16–21.
    OpenUrlPubMedWeb of Science
  3. ↵
    1. Nicolaos G.,
    2. Grauste-Manciet S.,
    3. Farinotti R.,
    4. Brossard D.
    Improvement of cefpodoxime proxetil oral absorption in rats by an oil-in-water submicron emulsion. Int. J. Pharm. 2003, 263 (1–2),165–171.
    OpenUrlPubMed
  4. ↵
    1. Jumaa M.,
    2. Müller B. W.
    The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions. Int. J. Pharm. 1998, 163 (1–2),81–89.
    OpenUrl
  5. ↵
    1. Mizushima Y.,
    2. Hamano T.,
    3. Yokoyama K.
    Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsions. Ann. Rheum. Dis. 1982, 41 (3),263–267.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Nasirideen S.,
    2. Kas H. S.,
    3. Oner F.,
    4. Alpar R.,
    5. Hincal A. A.
    Naproxen incorporated lipid emulsions. I formulation and stability studies. J. Clin. Pharm. Ther. 1998, 23 (1),55–65.
    OpenUrl
  7. ↵
    1. Valenta C.,
    2. Wanka M.,
    3. Heidlas J.
    Evaluation of novel soya lecithin formulation for dermal use containing Ketoprofen as a model drug. J. Controlled Release 2000, 63 (1–2),165–173.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Dietl H.
    Pharmaceutical Preparation Containing Cyclosporin(s) for Oral Administration and Process for Producing the Said Preparation. U.S. Patent 6,136,357, 1996.
  9. ↵
    1. Mizushima Y.,
    2. Yanagawa A.,
    3. Hoshik K.
    Prostaglandin E1 is more effective, when incorporated in lipid microspheres, for treatment of peripheral vascular disease in man. J. Pharm. Pharmacol. 1983, 35 (10),666–667.
    OpenUrlPubMedWeb of Science
  10. ↵
    1. Menasse R.,
    2. Hedwall P. R.,
    3. Kraetz J.,
    4. Pericin C.,
    5. Riesterer L.,
    6. Sallmann A.,
    7. Ziel R.,
    8. Jaques R.
    Pharmacological properties of diclofenac sodium and its metabolites. Scand. J. Rheumatol Suppl. 1978, 7 (22S),5–16.
    OpenUrl
  11. ↵
    1. Doreen M. S.,
    2. Boardman P. L.,
    3. Fowler P. D.,
    4. Poole P. H.
    Diclofenac (Voltarol) in rheumatoid arthritis: a report of a double-blind trial. Rheumatol. Rehabil. 1978, 17 (2),78–80.
    OpenUrl
  12. ↵
    1. Singh G.,
    2. Fort J. G.,
    3. Goldstein J. L.,
    4. Levy R. A.,
    5. Hanrahan P. S.,
    6. Bello A. E.,
    7. Andrade-Ortega L.,
    8. Wallemark C.,
    9. Agrawal N. M.,
    10. Eisen G. M.,
    11. Stenson W. F.,
    12. Triadafilopoulos G.
    SUCCESS-I Investigators. Celecoxib verses naproxen and diclofenac in osteoarthritis patients SUCCESS-I study. Am. J. Med. 2006, 119 (3),255–266.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    1. Willis J.,
    2. Kendall M. J.,
    3. Flinn R. M.,
    4. Thornhill D. P.,
    5. Welling P. G.
    The pharmacokinetics of diclofenac sodium following intravenous and oral administration. Eur. J. Clin. Pharmacol. 1979, 16 (6),405–410.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Kendall M. J.,
    2. Thornhill D. P.,
    3. Willis J. V.
    Factors affecting the pharmacokinetics of diclofenac sodium (Voltarol). Rheumatol. Rehabil. 1979, Suppl. 2, 38–46.
  15. ↵
    1. Kurowski M.
    Pharmacokinetics and biological activity of diclofenac preparation following intramuscular injection 75 mg and oral administration of 150 mg of active drug. Zeitschrift für Rheumatologie 1988, 47, 37–42.
    OpenUrlPubMed
  16. ↵
    1. Meyer S.,
    2. Berrut S.,
    3. Goodenough T. I. J.,
    4. Rajendram V. S.,
    5. Pinfield V. J.,
    6. Povey M. J. W.
    A comparative study of ultrasound and laser light diffraction techniques for particle size determination in dairy beverages. Meas. Sci. Technol. 2006, 17 (2),289–297.
    OpenUrl
  17. ↵
    1. Lieberman H. A.,
    2. Rieger M. M.,
    3. Banker G. S.
    Pharmaceutical Dosage Forms: Disperse Systems; Marcel Dekker: New York, 1988; Vol. 1.
  18. ↵
    1. Roland I.,
    2. Piel G.,
    3. Delattre L.,
    4. Evrard B.
    Systemic characterization of oil-in-water emulsions for formulation design. Int. J. Pharm. 2003, 263 (1–2),85–94.
    OpenUrlPubMed
  19. ↵
    1. Krishna G.,
    2. Wood G. C.,
    3. Sheth. B. B.
    Improving emulsification efficacy of lecithin by formulation design. I. Effect of adding secondary surfactant. PDA J. Pharm. Sci. Technol. 1998, 52 (6),331–336.
    OpenUrlAbstract/FREE Full Text
  20. ↵
    1. Asfak V.,
    2. Mrinalini D.,
    3. Leena B.,
    4. Rahul G.
    Simultaneous determination of diclofenac sodium and rabeprazole sodium in bulk and pharmaceutical dosage form by LC. Chromatographia 2007, 66 (11–12),941–943.
    OpenUrl
  21. ↵
    1. Khazaeinia T.,
    2. Jamali F.
    A comparison of gastrointestinal permeability induced by diclofenac phospholipid complex with diclofenac acid and its sodium salt. J. Pharm. Pharmceut. Sci. 2003, 6 (3),352–359.
    OpenUrl
  22. ↵
    1. Patlolla R. R.,
    2. Vobalaboina V.
    Pharmacokinetics and tissue distribution of Etoposide delivered in parenteral emulsion. J. Pharm. Sci. 2005, 94 (2),437–445.
    OpenUrlCrossRefPubMed
  23. ↵
    1. Bucci R.,
    2. Magri A. D.,
    3. Magri A. L.
    Determination of diclofenac salts in pharmaceutical formulations. Fresenius' J. Analyt. Chem. 1998, 362 (7–8),577–582.
    OpenUrl
  24. ↵
    1. Mahgoub A. A.
    Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat's paw oedema. Pharmacol. Res. 2002, 45 (1), 1–4.
    OpenUrlCrossRefPubMed
  25. ↵
    1. Turankar A. V.,
    2. Motghare V. M.,
    3. Dakhale G. N.,
    4. Shaikh P.,
    5. Khobragade L. R.,
    6. Jagtap S.
    . Anti-inflammatory activity of serratiopeptidase and its combination with diclofenac sodium in rats. Indian J. Pharmacol. 2003, 35 344–345.
    OpenUrl
  26. ↵
    1. Lee G. W. J.,
    2. Groves M. J.
    A pragmatic approach to the particle sizing of submicrometre emulsions using a laser nephalometer. Powder Technol. 1981, 28, 49–54.
    OpenUrl
  27. ↵
    1. Hansrani P. K.,
    2. Davis S. S.,
    3. Groves M. J.
    The preparation and properties of sterile intravenous emulsions. J. Parent. Sci. Technol. 1983, 37 (4),145–150.
    OpenUrl
  28. ↵
    1. Takamura A.,
    2. Ishii F.,
    3. Noro S.,
    4. Tanifuji M.,
    5. Nakajima S.
    Study of intravenous hyperalimentation: Effect of selected amino acids on the stability of intravenous fat emulsions. J. Pharm. Sci. 1984, 73 (1),91–94.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Shotton E.,
    2. Davis S. S.
    A note on the stability of emulsion on high dilution. J. Pharm. Pharmacol. 1968, 20 (11),825–829.
    OpenUrlPubMed
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PDA Journal of Pharmaceutical Science and Technology: 63 (5)
PDA Journal of Pharmaceutical Science and Technology
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September/October 2009
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Preparation, Characterization, and In Vivo Pharmacodynamic Evaluation of Parenteral Diclofenac Submicron Lipid Emulsions
Endabetla Varshika, Kandadi Prabhakar, Veerabrahma Kishan
PDA Journal of Pharmaceutical Science and Technology Sep 2009, 63 (5) 380-389;

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Preparation, Characterization, and In Vivo Pharmacodynamic Evaluation of Parenteral Diclofenac Submicron Lipid Emulsions
Endabetla Varshika, Kandadi Prabhakar, Veerabrahma Kishan
PDA Journal of Pharmaceutical Science and Technology Sep 2009, 63 (5) 380-389;
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