Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleRESEARCH

Preparation and Characterization of Poly Lactide-co-glycolide Nanoparticles of SN-38

P. Ebrahimnejad, R. Dinarvand, S. A. Sajadi, F. Atyabi, F. Ramezani and M. R. Jaafari
PDA Journal of Pharmaceutical Science and Technology November 2009, 63 (6) 512-520;
P. Ebrahimnejad
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Dinarvand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. A. Sajadi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Atyabi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Ramezani
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. R. Jaafari
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Kunii R.,
    2. Onishi H.,
    3. Ueki K.,
    4. Koyama K.,
    5. Machida Y.
    Particle characteristics and biodistribution of camptothecin-loaded PLA/(PEG-PPG-PEG) nanoparticles. Drug Delivery 2008, 15 ( 1), 3– 10.
    OpenUrlPubMed
  2. 2.↵
    1. Noda K.,
    2. Nishiwaki Y.,
    3. Kawahara M.,
    4. Negoro S.,
    5. Sugiura T.,
    6. Yokoyama A.,
    7. Fukuoka M.,
    8. Mori K.,
    9. Watanabe K.,
    10. Tamura T.,
    11. Yamamoto S.,
    12. Saijo N
    Japan Clinical Oncology Group. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N. Engl. J. Med. 2002, 346 ( 2), 85– 91.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Negoro S.,
    2. Masuda N.,
    3. Takada Y.
    CPT-11 Lung Cancer Study Group West. Randomised phase III trial of irinotecan combined with cisplatin for advanced non-small-cell lung cancer. Br. J. Cancer 2003, 88 ( 3), 335.
  4. 4.↵
    1. Bodurka D. C.,
    2. Levenback C.,
    3. Wolf J. K.
    Phase II trial of irinotecan in patients with metastatic epithelial ovarian cancer or peritoneal cancer. J. Clin. Oncol. 2003, 21 ( 2), 291– 297.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    Physician Desk Reference, Camptosar®, 57th ed. Thomson Healthcare, Montvale, N.J, 2003.
  6. 6.↵
    1. Rothenberg M. L.,
    2. Kuhn J. G.,
    3. Burris H. A., 3rd,
    4. Nelson J.,
    5. Eckardt J. R.,
    6. Tristan-Morales M.,
    7. Hilsenbeck S. G.,
    8. Weiss G. R.,
    9. Smith L. S.,
    10. Rodriguez G. I.,
    11. Rock M. K.,
    12. Von Hoff D. D.
    Phase I and pharmacokinetic trial of weekly CPT-11. J. Clin. Oncol. 1993, 11 ( 11), 2194– 2204.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Slatter J. G.,
    2. Schaff L. J.,
    3. Sams J. P.
    Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C] CPT-11 in cancer patients. Drug. Metab. Dispos. 2000, 28 ( 4), 423– 433.
    OpenUrlAbstract/FREE Full Text
  8. 8.↵
    1. Gupta E.,
    2. Lestingi T. M.,
    3. Mick R.,
    4. Ramirez J.,
    5. Vokes E. E.,
    6. Ratain M. J.
    Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea. Cancer Res. 1994, 54 ( 14), 3723– 3725.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Koizumi F.,
    2. Kitagawa M.,
    3. Negishi T.,
    4. Onda T.,
    5. Matsumota S.,
    6. Hamaguchi T.,
    7. Matsumura Y.
    Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. Cancer Res. 2006, 66 ( 20), 10048– 10056.
    OpenUrlAbstract/FREE Full Text
  10. 10.↵
    1. Chabner B. A.,
    2. Longo D. L.
    1. Takimoto C. H.,
    2. Arbuck S. G.
    Topoisomerase I targeting agents: The camptothecins. In Cancer Chemotherapy and Biotherapy: Principles and Practice; 3rd ed.; Chabner B. A., Longo D. L.Eds.; Lippincott Williams & Wilkins: Philadelphia, PA, 2001; p 579.
  11. 11.↵
    1. Zhang J. A.,
    2. Xuan T.,
    3. Ma M.,
    4. Parmer L.,
    5. Ugwu S.,
    6. Ali S.,
    7. Ahmad I.
    Development and characterization of a novel liposome-based formulation of SN-38. Int. J. Pharm. 2004, 270 ( 1–2), 93– 107.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Lie S.,
    2. Chien P. Y.,
    3. Sheikh S.,
    4. Zhang A.,
    5. Ali S.,
    6. Ahmad I.
    Enhanced therapeutic efficacy of a novel liposome-based formulation of SN-38 against human tumor models in SCID mice. Anticancer Drugs 2004, 15 ( 8), 773– 778.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Onishi Y.,
    2. Machida Y.
    Antitumor properties of irinotecan-containing nanoparticles prepared using poly (DL-lactic acid) and poly (ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol). Biol. Pharm. Bull. 2003, 26 ( 1), 116.
  14. 14.↵
    1. Esmaeili F.,
    2. Hosseini-Nasr M.,
    3. Rad-Malekshahi M.,
    4. Samadi N.,
    5. Atyabi F.,
    6. Dinarvand R.
    Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles. Nanomedicine: Nanotech. Biol. Medicine 2007, 3 ( 2), 161– 167.
    OpenUrl
  15. 15.↵
    1. Esmaeili F.,
    2. Ghahremani M. H.,
    3. Ostad S. N.,
    4. Atyabi F.,
    5. Seyedabadi M.,
    6. Malekshahi M. R.,
    7. Amini M.,
    8. Dinarvand R.
    Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate. J. Drug Targeting 2008, 16 ( 5), 415– 423.
    OpenUrl
  16. 16.↵
    1. Esmaeili F.,
    2. Ghahremani B.,
    3. Esmaeili B.,
    4. Khoshayand M. R.,
    5. Atyabi F.,
    6. Dinarvand R.
    PLGA nanoparticles of different surface properties: Preparation and evaluation of their body distribution. Int. J. Pharm. 2008, 349 ( 1–2), 249– 255.
    OpenUrlPubMed
  17. 17.↵
    1. Lockman R.,
    2. Mumper R. J.,
    3. Khan M. A.,
    4. Allen D. D.
    Nanoparticles technology for drug delivery across the blood-brain barrier. Drug Dev. Ind. Pharm. 2002, 28 ( 1), 1– 13.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Grief R.,
    2. Domb A.,
    3. Quellec P.,
    4. Blunk T.,
    5. Müller R. H.,
    6. Verbavatz J. M.,
    7. Langer R.
    The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv. Drug Del. Rev. 1995, 16 ( 2–3), 215– 233.
    OpenUrlCrossRef
  19. 19.↵
    1. Cappel J.,
    2. Kreuter J.
    Effect of nanoparticles on transdermal drug delivery. J. Microencapsul. 1991, 8 ( 3), 369– 374.
    OpenUrlPubMed
  20. 20.↵
    1. Arica B.,
    2. Lamprecht A.
    In vitro evaluation of betamethasone-loaded nanoparticles. Drug Del. Ind. Pharm. 2005, 31 ( 1), 19– 24.
    OpenUrl
  21. 21.↵
    1. Pal A.
    Preclinical safety, pharmacokinetics and antitumor efficacy profile of liposome-entrapped SN-38 formulation. Anticancer Res. 2005, 25 ( 1A), 331– 341.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Sumitomo M.,
    2. Koizumi F.,
    3. Asano T.,
    4. Horiguchi A.,
    5. Ito K.,
    6. Kakizoe T.,
    7. Hayakawa M.,
    8. Matsumura Y.
    Novel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression. Cancer Res. 2008, 68 ( 6), 1631– 1635.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Soppimath K. S.,
    2. Aminabhavi T. M.,
    3. Kulkarni A. R.,
    4. Rudzinski W. E.
    Biodegradable polymeric nanoparticles as drug delivery devices. J. Controlled Release 70 ( 1–2), 1– 20.
  24. 24.↵
    1. Mu L.,
    2. Feng S. S.
    A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. J. Controlled Release 2003, 86 ( 1), 33– 48.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Dong Y.,
    2. Feng S. S.
    Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. Biomaterials 2004, 25 ( 14), 2843– 2849.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Murakami H.,
    2. Kobayashi M.,
    3. Takeuchi Y.,
    4. Kawashima Y.
    Preparation of poly (DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method. Int. J. Pharm. 1999, 187 ( 2), 143– 152.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Niwa T.,
    2. Takeuchi H.,
    3. Hino T.,
    4. Kunou N.,
    5. Kawashima Y.
    In vitro drug release behavior of D, L-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method. J. Pharm. Sci. 1994, 83 ( 5), 727– 732.
    OpenUrlCrossRefPubMedWeb of Science
  28. 28.↵
    1. Le Roy Boehm A. L.,
    2. Zerrouk R.,
    3. Fessi H.
    Poly epsilon-caprolactone nanoparticles containing a poorly soluble pesticide: Formulation and stability study. J. Microencapsul. 2000, 17 ( 2), 195– 205.
    OpenUrlPubMed
  29. 29.↵
    1. Paul M.,
    2. Laatiris A.,
    3. Fessi H.,
    4. Dufeu B.,
    5. Durand B.,
    6. Deniau M.,
    7. Astier A.
    Pentamidine-loaded poly(D, L-lactide) nanoparticles: Adsorption and drug release. Drug Dev Res. 1998, 43 ( 2), 98– 104.
    OpenUrl
  30. 30.↵
    1. Garderton D.,
    2. Jones T.
    1. Holland S. J.,
    2. Tighe B. J.
    Biodegradable Polymers. In Advanced Pharmaceutical Science; Garderton D., Jones T.Eds; Academic Press: New York, 1992; Vol. 6, p 101.
    OpenUrl
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 63 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 63, Issue 6
November/December 2009
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Preparation and Characterization of Poly Lactide-co-glycolide Nanoparticles of SN-38
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
14 + 4 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Preparation and Characterization of Poly Lactide-co-glycolide Nanoparticles of SN-38
P. Ebrahimnejad, R. Dinarvand, S. A. Sajadi, F. Atyabi, F. Ramezani, M. R. Jaafari
PDA Journal of Pharmaceutical Science and Technology Nov 2009, 63 (6) 512-520;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Preparation and Characterization of Poly Lactide-co-glycolide Nanoparticles of SN-38
P. Ebrahimnejad, R. Dinarvand, S. A. Sajadi, F. Atyabi, F. Ramezani, M. R. Jaafari
PDA Journal of Pharmaceutical Science and Technology Nov 2009, 63 (6) 512-520;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • 1. Introduction and Objectives
    • 2. Materials and Methods
    • 3. Results and Discussion
    • 4. Conclusion
    • Acknowledgments
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Tumor-Specific Targeting of Pancreatic Cancer with Shiga Toxin B-Subunit
  • Google Scholar

More in this TOC Section

  • A Holistic Approach for Filling Volume Variability Evaluation and Control with Statistical Tool
  • A Proof-of-Concept Study on a Universal Standard Kit to Evaluate the Risks of Inspectors for Their Foundational Ability of Visual Inspection of Injectable Drug Products
  • Quantitative and Qualitative Evaluation of Microorganism Profile Identified in Bioburden Analysis in a Biopharmaceutical Facility in Brazil: Criteria for Classification and Management of Results
Show more Research

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire