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PDA Journal of Pharmaceutical Science and Technology

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Research ArticleRESEARCH

Generation of the Extractables Profile for an Elastomeric Material and Investigation of the Accumulation Behavior of Targeted Leachables Including Bis(2,2,6,6-tetramethyl-4-piperidyl) Sebacate (Tinuvin 770) and a Related Substance

James Story, Martha Gill, Norman Liu, Yousheng Hua and Dennis Jenke
PDA Journal of Pharmaceutical Science and Technology March 2010, 64 (2) 101-112;
James Story
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Martha Gill
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Norman Liu
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Yousheng Hua
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Dennis Jenke
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  • For correspondence: dennis_jenke@baxter.com
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References

  1. 1.↵
    1. Gill M.,
    2. Garber M. J.,
    3. Hua Y.,
    4. Jenke D.
    Development and validation of an HPLC/MS/MS method for quantitating Bis(2,2,6,6-tetramethyl-4-piperidinyl) sebacate (Tinuvin 770) and a related substance in aqueous extracts of plastic materials. J. Chromatogr. Sci. 2010, 48 (3), 200–207.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Glossmann H,
    2. Hering S.,
    3. Savchenko A.,
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    5. Friedrich K.,
    6. Garcia M. L.,
    7. Goetz M. A.,
    8. Liesch J. M.,
    9. Zinck D. L.,
    10. Kaczorowski G. J.
    A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca2+ channel blocker. Proc. Natl. Acad. Sci. 1993, 90 (20), 9523–9527.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Papke R. L.,
    2. Craig A. G.,
    3. Heinemann S. F.
    Inhibition of nicotic acethylcholine receptors by bis(2,2,6,6-trtramethyl-4-piperidinyl) sebacate (Tinuvin 770), an additive in medical plastics. J. Pharmacol. Exp. Ther. 1994, 268 (2), 717–726.
    OpenUrl
  4. 4.↵
    1. Sotonyl P,
    2. Keller E.,
    3. Jaray J.,
    4. Nemes B.,
    5. Benko T.,
    6. Kovacs A.,
    7. Tolokan A.,
    8. Rajis I.
    A light stabilizer Tinuvin 770-induced toxic injury of adult rat cardiac myoctes. Forensic Sci. Int. 2001, 119 (3), 322–327.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Sotonyi P,
    2. Merkely B.,
    3. Hubay M.,
    4. Jaray J.,
    5. Zima E.,
    6. Soos P.,
    7. Kovacs A.,
    8. Szentmariay I.
    Comparative study on cardiotoxic effect of Tinuvin 770: A light stabilizer of medical plastics in rat model. Toxicol. Sci. 2004, 77 (2), 368–374.
    OpenUrlAbstract/FREE Full Text
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PDA Journal of Pharmaceutical Science and Technology: 64 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 64, Issue 2
March/April 2010
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Generation of the Extractables Profile for an Elastomeric Material and Investigation of the Accumulation Behavior of Targeted Leachables Including Bis(2,2,6,6-tetramethyl-4-piperidyl) Sebacate (Tinuvin 770) and a Related Substance
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Generation of the Extractables Profile for an Elastomeric Material and Investigation of the Accumulation Behavior of Targeted Leachables Including Bis(2,2,6,6-tetramethyl-4-piperidyl) Sebacate (Tinuvin 770) and a Related Substance
James Story, Martha Gill, Norman Liu, Yousheng Hua, Dennis Jenke
PDA Journal of Pharmaceutical Science and Technology Mar 2010, 64 (2) 101-112;

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Generation of the Extractables Profile for an Elastomeric Material and Investigation of the Accumulation Behavior of Targeted Leachables Including Bis(2,2,6,6-tetramethyl-4-piperidyl) Sebacate (Tinuvin 770) and a Related Substance
James Story, Martha Gill, Norman Liu, Yousheng Hua, Dennis Jenke
PDA Journal of Pharmaceutical Science and Technology Mar 2010, 64 (2) 101-112;
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