A Novel Method of Characterizing Medicinal Drug Aerosols Generated from Pulmonary Drug Delivery Devices

References

1. 1.↵
   1. Hinds W. C.

   Aerosol Technology: Properties, Behavior and Measurement of Airborne Particles; John Wiley and Sons Inc.: New York, 1998.
2. 2.↵
   1. Finlay W. H.

   The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction; Academic Press: San Diego, 2001.
3. 3.↵
   1. Byron P. R.,
   2. Dalby R. N.,
   3. Farr S. J.

   1. Staniforth J. N.

   The Importance of Electrostatic Measurements in Aerosol Formulation and Pre-Formulation. In Respiratory Drug Delivery IV; Byron P. R., Dalby R. N., Farr S. J. Eds.; Interperm Press, Deerfield, Illinois, 1994; pp 303–311.
4. 4.↵
   1. Crowley J. M.

   Fundamentals of Applied Electrostatics; John Wiley and Sons, Inc.: New York, 1986.
5. 5.↵
   1. Bailey A. G.,
   2. Hashish A. H.,
   3. Williams T. J.

   Drug delivery by inhalation of charged particles. J. Electronics 1998, 44 (1–2), 3–10.

   OpenUrl
6. 6.↵
   1. Balachandran W.,
   2. Machowski W.,
   3. Gaura E.,
   4. Hudson C.

   Control of drug aerosol in human airways using electrostatic forces. J. Electrostatics 1997, 40, 579–584.

   OpenUrl
7. 7.↵
   1. Cohen B. S.,
   2. Xiong J. Q.,
   3. Fang C. P.,
   4. Li W.

   Deposition of charged particles on lung airways. Health Phys. 1998, 74 (5), 554–560.

   OpenUrlPubMedWeb of Science
8. 8.↵
   1. Hashish A. H.,
   2. Bailey A. G.,
   3. Williams T. J.

   Selective deposition of pulsed charged aerosols in the human lung. J. Aerosol Med. 1994, 7 (2), 167–171.

   OpenUrl
9. 9.↵
   1. Melandri C.,
   2. Tarroni G.,
   3. Prodi V.,
   4. Zaiacomo T. D.,
   5. Formignani M.,
   6. Lombardi C.

   Deposition of charged particles in the human airways. J. Aerosol Sci. 1983, 14 (5), 657–669.

   OpenUrlCrossRefWeb of Science
10. 10.↵
    1. Yu C. P.

    Precipitation of unipolarly charged particles in cylindrical and spherical vessel. J. Aerosol Sci. 1997, 8 (4), 237–241.

    OpenUrl
11. 11.↵
    1. Glover W.,
    2. Chan H. K.

    Electrostatic charge characterization of pharmaceutical aerosols using electrical low-power impaction (ELPI). J. Aerosol Sci. 2004, 35 (6), 755–764.

    OpenUrl
12. 12.↵
    1. Dalby R. N.,
    2. Byron P. R.,
    3. Peart J.,
    4. Suman J. D.,
    5. Farr S. J.

    1. Orban J. C.,
    2. Peart J.

    Simultaneous Electrostatic Charge Characterization and Particle Size Analysis of Metered Dose Inhalers (pMDIs) Using the Electrical Low Pressure Impactor. In Respiratory Drug Delivery IX; Dalby R. N., Byron P. R., Peart J., Suman J. D., Farr S. J. Eds.; Virginia Commonwealth University: Richmond, 2004; pp 877–880.
13. 13.↵
    1. Crapo J. D.

    1. Mazumder M. K.,
    2. Wilson J. D.,
    3. Wankum D. L.,
    4. Cole R.,
    5. Northrop G. M.,
    6. Neidhardt L. T.,
    7. Martonen T. B.

    Dual Laser Doppler System for Real-Time Simultaneous Characterization of Aerosols by Size and Concentration. In Lung Dosimetry; Crapo J. D. Ed.; Academic Press: San Diego, 1989; pp 211–234.
14. 14.↵
    1. Czarske J. W.

    Laser doppler velocimetry using powerful solid-state light sources. Meas. Sci. Technol. 2006, 17, R71–R91.

    OpenUrl
15. 15.↵
    1. Mazumder M. K.,
    2. Ware R. E.

    Aerosol Particles Charge and Size Analyzer. U.S. Patent 4,633,714, 1987.
16. 16.↵
    1. Ali M.,
    2. Mazumder M. K.,
    3. Martonen T. B.

    Measurements of electrodynamic effects on the deposition of MDI and DPI aerosols in a replica cast of human oral-pharyngeal-laryngeal airways. J. Aerosol Med. Pulmon. Drug Del. 2009, 22 (1), 35–44.

    OpenUrl
17. 17.↵
    1. Gradon J.,
    2. Marijnissen J.

    1. Cheng Y. S.

    Modeling Aerosol Drug Delivery. In Optimization of Aerosol Drug Delivery; Gradon J., Marijnissen J. Eds.; Kluwer Academic Publishers: Boston, 2003; pp 165–188.
18. 18.↵
    1. Fink J. B.

    Metered dose inhalers, dry powder inhalers and transitions. Respir. Care 2000, 45 (6), 623–635.

    OpenUrlPubMed
19. 19.↵
    1. Newman S.P.,
    2. Clarke A. R.,
    3. Talaee N.,
    4. Clarke S. W.

    Lung deposition of 5 mg Intal from a pressurized metered dose inhaler assessed by radiotracer technique. Intl. J. Pharmaceutics 1991, 74 (2–3), 203–208.

    OpenUrl
20. 20.↵
    1. Mitchell J.,
    2. Newman S. P.,
    3. Chan H. K.

    In vitro and in vivo aspects of cascade impactor tests and inhaler performance: a review. AAPS PharmSciTech 2007, 8 (4), E1–E12.

    OpenUrl
21. 21.↵
    1. Cross J. A.

    Electrostatics: Principles, Problems and Applications; Institute of Physics Publishing: Bristol, England, 1987.
22. 22.↵
    1. Evans A. E.,
    2. Ward S.,
    3. Prowse K.

    Respirable fraction and clinical response in relation to orifice size of aerosol inhalers. Thorax 1992, 47, 293P.

    OpenUrl
23. 23.↵
    1. Newman S. P.,
    2. Chan H. K.

    In vitro/in vivo comparisons in pulmonary drug delivery. J. Aerosol Med. Pulmon. Drug Del. 2008, 21 (1), 77–84.

    OpenUrl