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Research ArticleResearch

Iontophoretic Delivery of Acyclovir: Intradermal Drug Monitoring Using Microdialysis and Quantification by Skin Extraction

Srujana Siddoju, Vishal Sachdeva, Phillip M. Friden and Ajay K. Banga
PDA Journal of Pharmaceutical Science and Technology September 2011, 65 (5) 432-444; DOI: https://doi.org/10.5731/pdajpst.2011.00756
Srujana Siddoju
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Vishal Sachdeva
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Phillip M. Friden
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Ajay K. Banga
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  • For correspondence: banga_ak@mercer.edu
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References

  1. 1.↵
    1. Volpato N. M.,
    2. Nicoli S.,
    3. Laureri C.,
    4. Colombo P.,
    5. Santi P.
    In vitro acyclovir distribution in human skin layers after transdermal iontophoresis. J. Controlled Release 1998, 50 (1–3),291–296.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. Shukla C.,
    2. Friden P.,
    3. Juluru R.,
    4. Stagni G.
    In vivo quantification of acyclovir exposure in the dermis following iontophoresis of semisolid formulations. J. Pharm. Sci. 2009, 98 (3),917–925.
    OpenUrlPubMed
  3. 3.↵
    1. Stagni G.,
    2. Ali M. E.,
    3. Weng D.
    Pharmacokinetics of acyclovir in rabbit skin after i.v.-bolus, ointment, and iontophoretic administrations. Int. J. Pharm. 2004, 274 (1–2),201–211.
    OpenUrlPubMed
  4. 4.↵
    1. O'Brien J. J.,
    2. Campoli-Richards D. M.
    Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1989, 37 (3),233–309.
    OpenUrlPubMedWeb of Science
  5. 5.↵
    1. Parry G. E.,
    2. Dunn P.,
    3. Shah V. P.,
    4. Pershing L. K.
    Acyclovir bioavailability in human skin. J. Invest. Dermatol. 1992, 98 (6),856–863.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Volpato N. M.,
    2. Santi P.,
    3. Colombo P.
    Iontophoresis enhances the transport of acyclovir through nude mouse skin by electrorepulsion and electroosmosis. Pharm. Res. 1995, 12 (11),1623–1627.
    OpenUrlPubMed
  7. 7.↵
    1. Aungst B. J.,
    2. Rogers N. J.,
    3. Shefter E.
    Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides. Int. J. Pharm. 1986, 33 (1–3),225–234.
    OpenUrlCrossRef
  8. 8.↵
    1. Loftsson T.,
    2. Somogyi G.,
    3. Bodor N.
    Effect of choline esters and oleic acid on the penetration of acyclovir, estradiol, hydrocortisone, nitroglycerin, retinoic acid and trifluorothymidine across hairless mouse skin in vitro. Acta Pharm. Nord 1989, 1 (5),279–286.
    OpenUrlPubMed
  9. 9.↵
    1. Ranade V. V.
    Drug delivery systems. 6. Transdermal drug delivery. J. Clin. Pharmacol. 1991, 31 (5),401–418.
    OpenUrlPubMed
  10. 10.↵
    1. Santus G. C.,
    2. Baker R. W.
    Transdermal enhancer patent literature. J. Controlled Release 1993, 25 (1–2),1–20.
    OpenUrl
  11. 11.↵
    1. Lashmar U. T.,
    2. Manger J.
    Investigation of the potential for iontophoresis facilitated transdermal delivery of acyclovir. Int. J. Pharm. 1994, 111 (1),73–82.
    OpenUrl
  12. 12.↵
    1. Padula C.,
    2. Sartori F.,
    3. Marra F.,
    4. Santi P.
    The influence of iontophoresis on acyclovir transport and accumulation in rabbit ear skin. Pharm. Res. 2005, 22 (9),1519–1524.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Wearley L.,
    2. Chien Y.W.
    Enhancement of the in vitro skin permeability of azidothymidine (AZT) via iontophoresis and chemical enhancer. Pharm. Res. 1990, 7 (1),34–40.
    OpenUrlPubMed
  14. 14.↵
    1. Gay C. L.,
    2. Green P. G.,
    3. Guy R. H.,
    4. Francoeur M. L.
    Iontophoretic delivery of piroxicam across the skin in vitro. J. Controlled Release 1992, 22 (1),57–67.
    OpenUrl
  15. 15.↵
    1. Abla N.,
    2. Naik A.,
    3. Guy R. H.,
    4. Kalia Y. N.
    Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery. Pharm. Res. 2006, 23 (8),1842–1849.
    OpenUrlPubMedWeb of Science
  16. 16.↵
    1. Singh P.,
    2. Maibach H. I.
    Iontophoresis: an alternative to the use of carriers in cutaneous drug delivery. Adv. Drug. Deliv. Rev. 1996, 18 (3),379–394.
    OpenUrl
  17. 17.↵
    1. Banga A. K.
    Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies; CRC Press: Boca Raton, FL, 2011.
  18. 18.↵
    1. Guy R. H.,
    2. Kalia Y. N.,
    3. Delgado-Charro M. B.,
    4. Merino V.,
    5. Lopez A.,
    6. Marro D.
    Iontophoresis: electrorepulsion and electroosmosis. J. Controlled Release 2000, 64 (1–3),129–132.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Stagni G.,
    2. O'Donnell D.,
    3. Liu Y. J.,
    4. Kellogg D. L.,
    5. Morgan T.,
    6. Shepherd A. M.
    Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis. J. Controlled Release 2000, 63 (3),331–339.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Krogstad A. L.,
    2. Jansson P. A.,
    3. Gisslen P.,
    4. Lonnroth P.
    Microdialysis methodology for the measurement of dermal interstitial fluid in humans. Br. J. Dermatol. 1996, 134 (6),1005–1012.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Benfeldt E.
    In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects. Acta Derm. Venereol. Suppl. (Stockholm) 1999, 206, 1–59.
    OpenUrl
  22. 22.↵
    1. Borg N.,
    2. Gotharson E.,
    3. Benfeldt E.,
    4. Groth L.,
    5. Stahle L.
    Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers: comparison of the suction blister technique and cutaneous microdialysis. Acta Derm. Venereol. 1999, 79 (4),274–277.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Groth L.
    Cutaneous microdialysis. A new technique for the assessment of skin penetration. Curr. Probl. Dermatol. 1998, 26, 90–98.
    OpenUrlPubMed
  24. 24.↵
    1. Herkenne C.,
    2. Alberti I.,
    3. Naik A.,
    4. Kalia Y. N.,
    5. Mathy F. X.,
    6. Preat V.,
    7. Guy R. H.
    In vivo methods for the assessment of topical drug bioavailability. Pharm. Res. 2008, 25 (1),87–103.
    OpenUrlPubMed
  25. 25.↵
    1. Farfal S.,
    2. Klimowicz A.,
    3. Bielecka-Grzela S.
    Acyclovir concentrations in the skin of humans after a single oral dose assessed by in vivo cutaneous microdialysis. Skin. Res. Technol. 2006, 12 (4),228–234.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Morgan C. J.,
    2. Renwick A. G.,
    3. Friedmann P. S.
    The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis. Br. J. Dermatol. 2003, 148 (3),434–443.
    OpenUrlCrossRefPubMedWeb of Science
  27. 27.↵
    1. Klimowicz A.,
    2. Farfal S.,
    3. Bielecka-Grzela S.
    Evaluation of skin penetration of topically applied drugs in humans by cutaneous microdialysis: acyclovir vs. salicylic acid. J. Clin. Pharm. Ther. 2007, 32 (2),143–148.
    OpenUrlPubMed
  28. 28.↵
    1. Godin B.,
    2. Touitou E.
    Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. Adv. Drug Deliv. Rev. 2007, 59 (11),1152–1161.
    OpenUrlPubMed
  29. 29.↵
    1. Bronaugh R. L.,
    2. Stewart R. F.,
    3. Congdon E. R.
    Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol. Appl. Pharmacol. 1982, 62 (3),481–488.
    OpenUrlCrossRefPubMedWeb of Science
  30. 30.↵
    1. Kikwai L.,
    2. Babu R. J.,
    3. Prado R.,
    4. Kolot A.,
    5. Armstrong C. A.,
    6. Ansel J. C.,
    7. Singh M.
    In vitro and in vivo evaluation of topical formulations of Spantide II. AAPS PharmSciTech 2005, 6 (4),E565–E572.
    OpenUrlPubMed
  31. 31.↵
    1. Lauer A. C.,
    2. Elder J. T.,
    3. Weiner N. D.
    Evaluation of the hairless rat as a model for in vivo percutaneous absorption. J. Pharm. Sci. 1997, 86 (1),13–18.
    OpenUrlPubMed
  32. 32.↵
    1. Morimoto Y.,
    2. Hatanaka T.,
    3. Sugibayashi K.,
    4. Omiya H.
    Prediction of skin permeability of drugs: comparison of human and hairless rat skin. J. Pharm. Pharmacol. 1992, 44 (8),634–639.
    OpenUrlPubMedWeb of Science
  33. 33.↵
    1. Sachdeva V.,
    2. Siddoju S.,
    3. Yu Y. Y.,
    4. Kim H. D.,
    5. Friden P. M.,
    6. Banga A. K.
    Transdermal iontophoretic delivery of terbinafine hydrochloride: quantitation of drug levels in stratum corneum and underlying skin. Int. J. Pharm. 2010, 388 (1–2),24–31.
    OpenUrlPubMed
  34. 34.↵
    1. Sachdeva V.,
    2. Kim H. D.,
    3. Friden P. M.,
    4. Banga A. K.
    Iontophoresis mediated in vivo intradermal delivery of terbinafine hydrochloride. Int. J. Pharm. 2010, 393 (1–2),112–118.
    OpenUrlPubMed
  35. 35.↵
    1. Vemulapalli V.,
    2. Yang Y.,
    3. Friden P. M.,
    4. Banga A. K.
    Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate. J. Pharm. Pharmacol. 2008, 60 (1),27–33.
    OpenUrlPubMedWeb of Science
  36. 36.↵
    1. Volpato N. M.,
    2. Santi P.,
    3. Laureri C.,
    4. Colombo P.
    Assay of acyclovir in human skin layers by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 1997, 16 (3),515–520.
    OpenUrlPubMed
  37. 37.↵
    1. Kristl A.,
    2. Tukker J. J.
    Negative correlation of n-octanol/water partition coefficient and transport of some guanine derivatives through rat jejunum in vitro. Pharm. Res. 1998, 15 (3),499–501.
    OpenUrlPubMed
  38. 38.↵
    1. Kristl A.,
    2. Mrhar A.,
    3. Kozjek F.
    The ionisation properties of acyclovir and deoxyacyclovir. Int. J. Pharm. 1993, 99 (1),79–82.
    OpenUrl
  39. 39.↵
    1. Merino V.,
    2. López A.,
    3. Kalia Y. N.,
    4. Guy R. H.
    Electrorepulsion versus electroosmosis: effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm. Res. 1999, 16 (5),758–761.
    OpenUrlCrossRefPubMed
  40. 40.↵
    1. Stagni G.,
    2. O'Donnell D.,
    3. Liu Y. J.,
    4. Kellogg D.L. Jr..,
    5. Shepherd A. M.
    Iontophoretic current and intradermal microdialysis recovery in humans. J. Pharmacol. Toxicol. Methods 1999, 41 (1),49–54.
    OpenUrlCrossRefPubMed
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PDA Journal of Pharmaceutical Science and Technology: 65 (5)
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Iontophoretic Delivery of Acyclovir: Intradermal Drug Monitoring Using Microdialysis and Quantification by Skin Extraction
Srujana Siddoju, Vishal Sachdeva, Phillip M. Friden, Ajay K. Banga
PDA Journal of Pharmaceutical Science and Technology Sep 2011, 65 (5) 432-444; DOI: 10.5731/pdajpst.2011.00756

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Iontophoretic Delivery of Acyclovir: Intradermal Drug Monitoring Using Microdialysis and Quantification by Skin Extraction
Srujana Siddoju, Vishal Sachdeva, Phillip M. Friden, Ajay K. Banga
PDA Journal of Pharmaceutical Science and Technology Sep 2011, 65 (5) 432-444; DOI: 10.5731/pdajpst.2011.00756
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