Mouse Minute Virus (MMV) Contamination—A Case Study: Detection, Root Cause Determination, and Corrective Actions

Mark Moody; Washington Alves; Jose Varghese; Fazal Khan

doi:10.5731/pdajpst.2011.00824

OtherConference Proceeding

Mouse Minute Virus (MMV) Contamination—A Case Study: Detection, Root Cause Determination, and Corrective Actions

Mark Moody, Washington Alves, Jose Varghese and Fazal Khan

PDA Journal of Pharmaceutical Science and Technology November 2011, 65 (6) 580-588; DOI: https://doi.org/10.5731/pdajpst.2011.00824

Mark Moody

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: mmoody@merrimackpharma.com

Washington Alves

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jose Varghese

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Fazal Khan

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
References
Info & Metrics
PDF

Article Information

vol. 65 no. 6 580-588

DOI

https://doi.org/10.5731/pdajpst.2011.00824

PubMed

22294580

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online January 4, 2012.

Author Information

Mark Moody*,
Washington Alves,
Jose Varghese and
Fazal Khan

Merrimack Pharmaceuticals, Inc.

↵* Corresponding Author: Merrimack Pharmaceuticals, Inc., 1 Kendall Square, Suite B7201, Cambridge, MA 02139-1670. E-mail: mmoody{at}merrimackpharma.com.

View Full Text

Cited By...

44 Citations
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Scale‐up economics for cultured meat

David Humbird

Biotechnology and Bioengineering 2021 118 8
Viral contamination in biologic manufacture and implications for emerging therapies

Paul W. Barone, Michael E. Wiebe, James C. Leung, Islam T. M. Hussein, Flora J. Keumurian, James Bouressa, Audrey Brussel, Dayue Chen, Ming Chong, Houman Dehghani, Lionel Gerentes, James Gilbert, Dan Gold, Robert Kiss, Thomas R. Kreil, René Labatut, Yuling Li, Jürgen Müllberg, Laurent Mallet, Christian Menzel, Mark Moody, Serge Monpoeho, Marie Murphy, Mark Plavsic, Nathan J. Roth, David Roush, Michael Ruffing, Richard Schicho, Richard Snyder, Daniel Stark, Chun Zhang, Jacqueline Wolfrum, Anthony J. Sinskey, Stacy L. Springs

Nature Biotechnology 2020 38 5
Removal of xenotropic murine leukemia virus by nanocellulose based filter paper

M. Asper, T. Hanrieder, A. Quellmalz, A. Mihranyan

Biologicals 2015 43 6
Mille-feuille paper: a novel type of filter architecture for advanced virus separation applications

Simon Gustafsson, Pascal Lordat, Tobias Hanrieder, Marcel Asper, Oliver Schaefer, Albert Mihranyan

Materials Horizons 2016 3 4
Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines

Abel Ramos-Vega, Sergio Rosales-Mendoza, Bernardo Bañuelos-Hernández, Carlos Angulo

Frontiers in Microbiology 2018 9
CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation

Gabriel Byrne, Sara M. O’Rourke, David L. Alexander, Bin Yu, Rachel C. Doran, Meredith Wright, Qiushi Chen, Parastoo Azadi, Phillip W. Berman, Sarah Rowland-Jones

PLOS Biology 2018 16 8
A novel approach to achieving modular retrovirus clearance for a parvovirus filter

Juliana Stuckey, Daniel Strauss, Adith Venkiteshwaran, Jinxin Gao, Wen Luo, Michelle Quertinmont, Sean O'Donnell, Dayue Chen

Biotechnology Progress 2014 30 1
New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins

Brian Kelley, Robert Kiss, Michael Laird

2018 165
Growth media filtration using nanocellulose-based virus removal filter for upstream biopharmaceutical processing

Levon Manukyan, Pengfei Li, Simon Gustafsson, Albert Mihranyan

Journal of Membrane Science 2019 572
Mechanistic insights into flow-dependent virus retention in different nanofilter membranes

Remo Leisi, Eleonora Widmer, Barry Gooch, Nathan J. Roth, Carlos Ros

Journal of Membrane Science 2021 636
Virus disinfection for biotechnology applications: Different effectiveness on surface versus in suspension

Johanna Kindermann, Michael Karbiener, Sandra M. Leydold, Simone Knotzer, Jens Modrof, Thomas R. Kreil

Biologicals 2020 64
Inactivation of Caliciviruses

Raymond Nims, Mark Plavsic

Pharmaceuticals 2013 6 3
Evaluating ultraviolet sensitivity of adventitious agents in biopharmaceutical manufacturing

Sarah M Meunier, Michael R Sasges, Marc G Aucoin

Journal of Industrial Microbiology and Biotechnology 2017 44 6
Nanofiltration of growth media supplemented with human platelet lysates for pathogen-safe xeno-free expansion of mesenchymal stromal cells

Lassina Barro, Ouada Nebie, Ming-Sheng Chen, Yu-Wen Wu, Mickey BC Koh, Folke Knutson, Naoto Watanabe, Masayasu Takahara, Thierry Burnouf

Cytotherapy 2020 22 8
Determination of parvovirus retention profiles in virus filter membranes using laser scanning microscopy

Remo Leisi, Jan Bieri, Nathan J. Roth, Carlos Ros

Journal of Membrane Science 2020 603
Untargeted LC-MS/MS Profiling of Cell Culture Media Formulations for Evaluation of High Temperature Short Time Treatment Effects

Patrick Floris, Nicola McGillicuddy, Simone Albrecht, Brian Morrissey, Christian Kaisermayer, Anna Lindeberg, Jonathan Bones

Analytical Chemistry 2017 89 18
Impact of Dissolved Oxygen during UV-Irradiation on the Chemical Composition and Function of CHO Cell Culture Media

Sarah M. Meunier, Biljana Todorovic, Emma V. Dare, Afroza Begum, Simon Guillemette, Andrew Wenger, Priyanka Saxena, J. Larry Campbell, Michael Sasges, Marc G. Aucoin, Maria Cristina Vinci

PLOS ONE 2016 11 3
Choice of parvovirus model for validation studies influences the interpretation of the effectiveness of a virus filtration step

Thomas Nowak, Birgit Popp, Nathan J. Roth

Biologicals 2019 60
The Role of Nanofiltration in the Pathogen Safety of Biologicals: An Update

Masaharu Inouye, Thierry Burnouf

Current Nanoscience 2020 16 3
Cell Culture Engineering

Simon Fischer, Kerstin Otte

2019
Genetic engineering of CHO cells for viral resistance to minute virus of mice

Joaquina X. Mascarenhas, Nikolay Korokhov, Lisa Burger, Ademola Kassim, Jason Tuter, Daniel Miller, Trissa Borgschulte, Henry J. George, Audrey Chang, David J. Pintel, David Onions, Kevin J. Kayser

Biotechnology and Bioengineering 2017 114 3
Impact of the isoelectric point of model parvoviruses on viral retention in anion‐exchange chromatography

Remo Leisi, Raphael Wolfisberg, Thomas Nowak, Oliver Caliaro, Andreas Hemmerle, Nathan J. Roth, Carlos Ros

Biotechnology and Bioengineering 2021 118 1
Visualizing protein fouling and its impact on parvovirus retention within distinct filter membrane morphologies

Remo Leisi, Iman Rostami, Andrew Laughhunn, Jan Bieri, Nathan J. Roth, Eleonora Widmer, Carlos Ros

Journal of Membrane Science 2022 659
Measuring the effectiveness of gaseous virus disinfectants

Simone Knotzer, Johanna Kindermann, Jens Modrof, Thomas R. Kreil

Biologicals 2015 43 6
k -mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing

Madolyn L. MacDonald, Shawn W. Polson, Kelvin H. Lee, Angela L. Rasmussen

mSphere 2021 6 2
Considerations for risk and control of mycoplasma in bioprocessing

Phillip Angart, Casey Kohnhorst, Meng-Jung Chiang, Nilou Sarah Arden

Current Opinion in Chemical Engineering 2018 22
Successful removal of porcine circovirus-1 from immunoglobulin G formulated in glycine solution using nanofiltration

Rong-Mei Bao, Akemi Shibuya, Takashi Uehira, Tetsuo Sato, Takeru Urayama, Kaoru Sakai, Mikihiro Yunoki

Biologicals 2018 51
ICH Quality Guidelines

Daniel Galbraith

2017
ICH Quality Guidelines

Mark Plavsic

2017
Ultraviolet irradiation of trypsin, lysozyme and β-galactosidase: how does UVC affect these enzymes when used as a secondary barrier against adventitious agents?

Michelle A. Gabriel, Emma V. Dare, Sarah M. Meunier, J. Larry Campbell, Michael R. Sasges, Marc G. Aucoin

Vaccine 2019 37 43
Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry

Leïla Djemal, Clemence Fournier, Joerg von Hagen, Harald Kolmar, Véronique Deparis

Biotechnology Progress 2021 37 3
Continuous Biomanufacturing ‐ Innovative Technologies and Methods

Andrew Clutterbuck, Michael A. Cunningham, Cedric Geyer, Paul Genest, Mathilde Bourguignat, Helge Berg

2017
Detection of Minute virus of mice strains in different cell lines: Implications for adventitious agent testing

Maria R. Farcet, Jens Modrof, Gerhard Antoine, Cecilie Klausen, Astrid Kerschbaum, Martina Kopp, Houman Dehghani, Thomas R. Kreil

Biotechnology and Bioengineering 2024 121 1
The effect of hydrogen peroxide produced during ultraviolet disinfection of CHO cell culture media

Emma V. Dare, Michelle Gabriel, Afroza Begum, Michael Sasges, Marc G. Aucoin

Process Biochemistry 2017 61
Identification of infectious viruses for risk‐based virus testing of CHO unprocessed bulk using next‐generation sequencing

Tiffany Hsu, Mary Jo Talley, Ping Yang, Angela Geiselhoeringer, Cindy Yang, Aditya Gorla, M. Julhasur Rahman, Lindsey Silva, Dayue Chen, Bin Yang

Biotechnology Progress 2024 40 6
Kirk-Othmer Encyclopedia of Chemical Technology

Daniel Strauss, Linda Gudex, Hironobu Shirataki

2023
Low-Energy Electron Irradiation Inactivates Viruses in Serum and Maintains Growth-Promoting Properties in Cell Culture

Jasmin Fertey, Gustavo R. Makert, Philipp Becker, Julia Finkensieper, Sebastian Ulbert

Applied Biosafety 2025
Mammalian Cell Cultures for Biologics Manufacturing

Dayue Chen

2013 139
Mechanistic model of minute virus of mice elution behavior in anion exchange chromatography purification

Ryunosuke Kitamura, Lena Enghauser, Riku Miyamoto, Takahiro Ichikawa, Takaki Aiso, Yumiko Masuda, Daisuke Kajihara, Hirofumi Kakihara, Koichi Nonaka

Biotechnology Progress 2025 41 2
Protection of biomanufacturing processes from virus contamination through upstream virus filtration of cell culture media

Andreas Wieser, Jens Modrof, Thomas R. Kreil

Biotechnology and Bioengineering 2023 120 10
Protein Therapeutics

Kripa Ram, Diane Hatton, Sanjeev Ahuja, Jean Bender, Alan Hunter, Richard Turner

2016 21
Revisiting mouse minute virus inactivation by high temperature short time treatment

Joleen Su, Jonathan Rice, Jacob Hoffman, Shelley Alvarado, Mark Bailey, Martina Kopp, Marie Murphy, Robert Kiss, Paul W. Barone, Michael E. Wiebe, Stacy L. Springs, Houman Dehghani, Dayue Chen

Biotechnology and Bioengineering 2021 118 8
The Challenge of CMC Regulatory Compliance for Biopharmaceuticals

John Geigert

2019
The Challenge of CMC Regulatory Compliance for Biopharmaceuticals and Other Biologics

John Geigert

2013

PreviousNext

In This Issue

PDA Journal of Pharmaceutical Science and Technology

Vol. 65, Issue 6

November/December 2011

Table of Contents
Index by Author

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Mouse Minute Virus (MMV) Contamination—A Case Study: Detection, Root Cause Determination, and Corrective Actions

Message Subject (Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology

Message Body (Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Math question * 4 + 0 =

Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Citation Tools

Mouse Minute Virus (MMV) Contamination—A Case Study: Detection, Root Cause Determination, and Corrective Actions

Mark Moody, Washington Alves, Jose Varghese, Fazal Khan

PDA Journal of Pharmaceutical Science and Technology Nov 2011, 65 (6) 580-588; DOI: 10.5731/pdajpst.2011.00824

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Mouse Minute Virus (MMV) Contamination—A Case Study: Detection, Root Cause Determination, and Corrective Actions

Mark Moody, Washington Alves, Jose Varghese, Fazal Khan

PDA Journal of Pharmaceutical Science and Technology Nov 2011, 65 (6) 580-588; DOI: 10.5731/pdajpst.2011.00824

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Jump to section

Article
Figures & Data
References
Info & Metrics
PDF

No related articles found.

PubMed
Google Scholar

Cited By...

k-mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing
CRISPR/Cas9 gene editing for the creation of an MGAT1 deficient CHO cell line to control HIV-1 vaccine glycosylation
Detection of Adventitious Agents Using Next-Generation Sequencing
Meeting Report: 2013 PDA Virus & TSE Safety Forum
Use of MMV as a Single Worst-Case Model Virus in Viral Filter Validation Studies

Google Scholar

Conference Proceeding

Proceedings of the 2017 Viral Clearance Symposium, Session 3: Resin Lifetime
Proceedings of the 2017 Viral Clearance Symposium, Session 1.1: Upstream Mitigation, Part 1—Cell Bank and Bulk Harvest Testing
Proceedings of the 2017 Viral Clearance Symposium, Session 6: Ensuring Viral Safety in Continuous Processing

Show more Conference Proceeding

Plenary Session 3 and 4: Review and Viral Contamination and Case Studies

Case Study of Apparent Virus Contamination in Biopharmaceutical Product at Centocor
Identification and Remediation of a Cell Culture Virus Contamination
A Biotech Production Facility Contamination Case Study—Minute Mouse Virus

Show more Plenary Session 3 and 4: Review and Viral Contamination and Case Studies

Paper

Regulatory Approaches for Control of Viral Contamination of Vaccines
Practicing Safe Cell Culture: Applied Process Designs for Minimizing Virus Contamination Risk
Massively Parallel Sequencing for the Detection of Adventitious Viruses

Show more Paper

Main menu

User menu

Search

Mouse Minute Virus (MMV) Contamination—A Case Study: Detection, Root Cause Determination, and Corrective Actions

Article Information

Author Information

Cited By...

In This Issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Conference Proceeding

Plenary Session 3 and 4: Review and Viral Contamination and Case Studies

Paper

Similar Articles

Readers

Author/Reviewer Information

Parenteral Drug Association, Inc.