Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
OtherConference Proceeding

Practicing Safe Cell Culture: Applied Process Designs for Minimizing Virus Contamination Risk

Robert D. Kiss
PDA Journal of Pharmaceutical Science and Technology November 2011, 65 (6) 715-729; DOI: https://doi.org/10.5731/pdajpst.2011.00852
Robert D. Kiss
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Liu. S.,
    2. Carroll M.,
    3. Iverson R.,
    4. Valera C.,
    5. Vennari J.,
    6. Turco K.,
    7. Piper. R.,
    8. Kiss R.,
    9. Lutz H.
    Development and qualification of a novel virus removal filter for cell culture applications. Biotechnol. Prog. 2000, 16 (3), 425–434.
    OpenUrlPubMed
  2. 2.↵
    1. Okita W. B.
    Sustainable Commercial Cell Culture Operations. IBC Conference Presentation, September 2010, Providence, RI.
  3. 3.↵
    1. Garnick R.
    Experience with viral contamination in cell culture. Dev. Biol. Stand. 1996, 88, 49–56.
    OpenUrlPubMed
  4. 4.↵
    1. Garnick R.
    Raw materials as a source of contamination in large-scale cell culture. Dev. Biol. Stand. 1998, 93, 21–29.
    OpenUrlPubMedWeb of Science
  5. 5.↵
    1. Astell C.,
    2. Gardiner E.,
    3. Tattersall P.
    DNA Sequence of the lymphotropic variant of minute virus of mice, MVM(i), and comparison with the DNA sequence of the fibrotropic prototype strain. J. Virol. 1986, 57 (2), 656–669.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Dehghani H.
    Effectiveness of Media Treatment Technologies As Barriers to Adventitious Contaminants of Cell Culture. IBC Conference Presentation, September 2010, Providence, RI.
  7. 7.↵
    Genentech internal study, 1994 (unpublished results).
  8. 8.↵
    1. Boychyn R. M.
    Design of a Contamination Barrier for Serum-Containing Cell Culture Media of a Licensed Product, IBC Conference Presentation, September 2010, Providence, RI.
  9. 9.↵
    1. Kiss R.,
    2. Widrig R.,
    3. Magreta P.,
    4. Quan C.,
    5. Cacia J.
    Validation of Viral Barriers for Large Scale Cell Culture Medium. American Chemical Society Division of Biochemical Technology Presentation, April 1997, San Francisco, CA.
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 65 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 65, Issue 6
November/December 2011
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Practicing Safe Cell Culture: Applied Process Designs for Minimizing Virus Contamination Risk
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
6 + 9 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Practicing Safe Cell Culture: Applied Process Designs for Minimizing Virus Contamination Risk
Robert D. Kiss
PDA Journal of Pharmaceutical Science and Technology Nov 2011, 65 (6) 715-729; DOI: 10.5731/pdajpst.2011.00852

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Practicing Safe Cell Culture: Applied Process Designs for Minimizing Virus Contamination Risk
Robert D. Kiss
PDA Journal of Pharmaceutical Science and Technology Nov 2011, 65 (6) 715-729; DOI: 10.5731/pdajpst.2011.00852
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Genentech's Virus Contamination Events
    • Assessing the Risk of Virus Contamination
    • Upstream Virus Barrier Technology Options and Assessment
    • Development and Implementation of Additional Cell Culture Process Virus Barriers
    • Downstream Process Virus Barriers (Clearance)
    • Overall Virus Barrier Program in Biologics Manufacturing
    • Lessons Learned and Conclusions
    • Acknowledgments
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Detection of Adventitious Agents Using Next-Generation Sequencing
  • Case Study: A Novel Bacterial Contamination in Cell Culture Production--Leptospira licerasiae
  • Google Scholar

More in this TOC Section

Conference Proceeding

  • Proceedings of the 2017 Viral Clearance Symposium, Session 3: Resin Lifetime
  • Proceedings of the 2017 Viral Clearance Symposium, Session 1.1: Upstream Mitigation, Part 1—Cell Bank and Bulk Harvest Testing
  • Proceedings of the 2017 Viral Clearance Symposium, Session 6: Ensuring Viral Safety in Continuous Processing
Show more Conference Proceeding

Plenary Session 7: Process Design Strategies for Prevention of Viral Contaminations

  • Viral Safety of Plasma-derived Products
  • Application of Risk Assessments in the Design of the Overall Viral Control Strategy Used during the Manufacture and Testing of Live Virus Vaccines
Show more Plenary Session 7: Process Design Strategies for Prevention of Viral Contaminations

Paper

  • Risk Mitigation Strategies for Viral Contamination of Biotechnology Products: Consideration of Best Practices
  • Evaluation of a Single-Platform, Rapid, Nucleic Acid–Based Technology for Detection of Adventitious Contaminants of Cell Culture
  • Adventitious Agents: Issues and Considerations during Pre-Approval Reviews and Inspections
Show more Paper

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire