Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Review ArticleReview

The Effect of Radiation on a Variety of Pharmaceuticals and Materials Containing Polymers

Mine Silindir and Yekta Özer
PDA Journal of Pharmaceutical Science and Technology March 2012, 66 (2) 184-199; DOI: https://doi.org/10.5731/pdajpst.2012.00774
Mine Silindir
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yekta Özer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ayozer@hacettepe.edu.tr yktzer@yahoo.com
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Harrison J. D.,
    2. Stather J. W.
    The assessment of doses and effects from intakes of radioactive particles. J. Anat. 1996, 189 (Pt. 3), 521– 530.
    OpenUrlPubMed
  2. 2.↵
    1. Gopal N. G. S.
    Radiation sterilization of pharmaceuticals and polymers. Radiat. Phys. Chem. 1977, 12 (1–2),35– 50.
    OpenUrl
  3. 3.↵
    1. Guillard V.,
    2. Mauricio-Iglesias M.,
    3. Gontard N.
    Effect of novel food processing methods on packaging: structure, composition, and migration properties. Crit. Rev. Food Sci. Nutr. 2010, 50 (10),969– 988.
    OpenUrlPubMed
  4. 4.↵
    1. Arı İ. G.
    Radyasyonun Madde ile Etkileşimi ve Polimerler. Endüstride Radyasyonla Sterilizasyonda Kalite Kontrolü ve Kalite Temini Uygulamaları Kursu, Türkiye Atom Enerjisi Kurumu Ankara Nükleer Araştırma ve Eğitim Merkezi, Gama Işınlama Tesisi, Sarayköy, Ankara, 20– 24 November 1995.
  5. 5.↵
    1. Morrissey R. F.,
    2. Herring C. M.
    Radiation sterilization: past, present and future. Radiat. Phys. Chem. 2002, 63 (3–6),217– 221.
    OpenUrl
  6. 6.↵
    International Atomic Energy Agency, Directory of Gamma Processing Facilities in Member States; IAEA-DGPF-CD; IAEA: Vienna, 2004.
  7. 7.↵
    1. Chmielewski A. G.,
    2. Berejka A. J.
    Radiation Sterilization Centres Worldwide. In Trends in Radiation Sterilization of Health Care Products; IAEA: Vienna, 2008; pp 49– 61.
  8. 8.↵
    1. Başgül M.
    Radyasyonun Farmasötikler Üzerine Etkileri. Endüstride Radyasyonla Sterilizasyonda Kalite Kontrolü ve Kalite Temini Uygulamaları Kursu, Türkiye Atom Enerjisi Kurumu Ankara Nükleer Araştırma ve Eğitim Merkezi, Gama Işınlama Tesisi, Sarayköy, Ankara, 20– 24 November 1995.
  9. 9.↵
    1. Jefferson S.
    Manual on Radiosterilization of Medical and Biological Materials, Technical Reports Series No. 149; IAEA: Vienna, 1973; pp 89– 95.
  10. 10.↵
    1. Ishigaki I.,
    2. Yoshii F.
    Radiation effects on polymer materials in radiation sterilization of medical supplies. Int. J. Radiat. Appl. Instrument. 1992, 39 (6),527– 533.
    OpenUrl
  11. 11.↵
    1. Gürsoy A. Z.
    Farmasötik Teknoloji–Temel Konular ve Dozaj Şekilleri, Kontrollü Salım Sistemleri Derneği: İstanbul, 2004; pp 101– 115.
  12. 12.↵
    1. Jacobs G. P.
    Radiation sterilization of parenterals. 2007. http://pharmtech.findpharma.com/pharmtech/Aseptic+processing/Radiation-Sterilization-of-Parenterals/ArticleStandard/Article/detail/423948.
  13. 13.↵
    1. Al-Mohizea A. M.,
    2. El-Bagory I. M.,
    3. Alsarra I. A.,
    4. Al-Jenoobi F. I.,
    5. Bayomi M. A.
    Effect of gamma radiation on the physicochemical properties of ciprofloxacin in solid state. J. Drug Del. Sci. Technol. 2007, 17 (3),211– 215.
    OpenUrl
  14. 14.↵
    1. Maquille A.,
    2. Jiwan J. L. H.,
    3. Tilquin B.
    Radiosterilization of drugs in aqueous solutions may be achieved by the use of radioprotective excipients. Int. J. Pharm. 2008, 349 (1–2),74– 82.
    OpenUrlPubMed
  15. 15.↵
    1. Polat M.,
    2. Korkmaz M.
    Effect of gamma radiation on amlodis and its potential for radiosterilization. J. Pharm. Biomed. Anal. 2006, 40 (4),882– 888.
    OpenUrlPubMed
  16. 16.↵
    1. Maksimenko O.,
    2. Pavlov E.,
    3. Toushov E.,
    4. Molin A.,
    5. Stukalov Y.,
    6. Prudskova T.,
    7. Feldman V.,
    8. Kreuter J.,
    9. Gelperina S.
    Radiation sterilisation of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles. Int. J. Pharm. 2008, 356 (1–2),325– 332.
    OpenUrlPubMed
  17. 17.↵
    1. Mukherjee R. N.
    Radiation: A Means of Sterilization. www.iaea.org/Publications/Magazines/Bulletin/…/17605882837.pdf.
  18. 18.↵
    Guidelines for Validation, Radiation Sterilization, Sterigenics. www.sterigenics.com.
  19. 19.↵
    1. Lambert B. J.
    Sterilisation: material compatibility challenges and guidance for combination products. 2010. http://www.emdt.co.uk/article/sterilisation-material-compatibility-challenges.
  20. 20.↵
    Association for the Advancement of Medical Instrumentation (AAMI) TIR33:2005, Sterilisation of Healthcare Products, Radiation, Substantiation of a Selected Dose, Method VDmax.
  21. 21.↵
    Association for the Advancement of Medical Instrumentation (AAMI) TIR17:2008, (Revision of AAMI TIR17:1997), Technical Information Report, Compatibility of Materials Subject to Sterilization.
  22. 22.↵
    1. Association for the Advancement of Medical Instrumentation (AAMI)
    TIR17:1997, Technical Information Report, Radiation Sterilization-Material Qualification.
  23. 23.↵
    1. Igartua M.,
    2. Hernandez R. M.,
    3. Rosas J. E.,
    4. Patarroyo M. E.,
    5. Pedraz J. L.
    Gamma-irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine. Eur. J. Pharm. Biopharm. 2008, 69 (2),519– 526.
    OpenUrlCrossRefPubMed
  24. 24.↵
    1. Phillips G. O.
    Manual on Radiosterilization of Medical and Biological Materials, Technical Reports Series No. 149; IAEA: Vienna, 1973; pp 207– 228.
  25. 25.↵
    1. Garcia R.,
    2. Howard B.,
    3. LaRue R.,
    4. Parton G.,
    5. Walker J.
    Sterilization, Strategies for gamma sterilization of pharmaceuticals. Pharmaceutical & Medical Packaging 2004, 1, 1– 4. http://www.pmpnews.com/.
    OpenUrl
  26. 26.↵
    1. Ražem D.,
    2. Katusin-Ražem B.
    The effects of irradiation on controlled drug delivery/controlled drug release systems. Radiat. Phys. Chem. 2008, 77 (3),288– 344.
    OpenUrl
  27. 27.↵
    1. Da Costa Martins R.,
    2. Gamazo C.,
    3. Irache J. M.
    Design and influence of γ-irradiation on the biopharmaceutical properties of nanoparticles containing an antigenic complex from Brucella ovis. Eur. J. Pharm. Sci. 2009, 37 (5),563– 572.
    OpenUrlPubMed
  28. 28.↵
    1. Dorati R.,
    2. Colonna C.,
    3. Serra M.,
    4. Genta I.,
    5. Modena T.,
    6. Pavanetto F.,
    7. Perugini P.,
    8. Conti B.
    Gamma-irradiation of PEGd, IPLA and PEG-PLGA multiblock copolymers: I. Effect of irradiation doses. AAPS PharmSciTech. 2008, 9 (2),718– 725.
    OpenUrlPubMed
  29. 29.↵
    1. Puthli S.,
    2. Vavia P.
    Gamma irradiated micro system for long-term parenteral contraception: An alternative to synthetic polymers. Eur. J. Pharm. Sci. 2008, 35 (4),307– 317.
    OpenUrlPubMed
  30. 30.↵
    1. Martinez-Sancho C.,
    2. Herrero-Vanrell R.,
    3. Negro S.
    Study of gamma-irradiation effects on aciclovir poly(D,L-lactic-co-glycolic) acid microspheres for intravitreal administration. J. Control. Release. 2004, 99 (1),41– 52.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Bozdag S.,
    2. Dillen K.,
    3. Vandervoort J.,
    4. Ludwig A.
    The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(D,L-lactide-glycolide) nanoparticles. J. Pharm. Pharmacol. 2005, 57 (6),699– 707.
    OpenUrlPubMed
  32. 32.↵
    1. Shameem M.,
    2. Lee H.,
    3. Burton K.,
    4. Thanoo B. C.,
    5. Deluca P. P.
    Effect of gamma-irradiation on peptide-containing hydrophilic poly(d,l-lactide-co-glycolide) microspheres. PDA J. Pharm. Sci. Technol. 1999, 53, 309– 313.
    OpenUrlAbstract/FREE Full Text
  33. 33.↵
    1. Maquille A.,
    2. Habib Jiwan J. L.,
    3. Tilquin B.
    Cryo-irradiation as a terminal method for the sterilization of drug aqueous solutions. Eur. J. Pharm. Biopharm. 2008, 69 (1),358– 63.
    OpenUrlPubMed
  34. 34.↵
    1. Laufman H.,
    2. Rubel T.
    Synthetic absorbable sutures. Surg. Gynecol. Obstet. 1977, 145 (4),597– 608.
    OpenUrlPubMedWeb of Science
  35. 35.↵
    1. Sintzel M. B.,
    2. Merkli A.,
    3. Tabatabay C.,
    4. Gurny R.
    Influence of irradiation sterilization on polymers used as drug carriers: a review. Drug Dev. Ind. Pharm. 1997, 23 (9),857– 878.
    OpenUrl
  36. 36.↵
    1. El Maghraby G. M.,
    2. Bosela A. A.
    Investigation of self-microemulsifying and microemulsion systems for protection of prednisolone from gamma radiation. Pharm. Dev. Technol. 2010, 16 (3),237– 242.
    OpenUrlPubMed
  37. 37.↵
    1. Harrington K. J.,
    2. Rowlinson-Busza G.,
    3. Syrigos K. N.,
    4. Uster P. S.,
    5. Vile R. G.,
    6. Peters A. M.,
    7. Stewart J. S.
    The effect of irradiation on the biodistribution of Radiolabeled PEGylated liposomes. Int. J. Radiat. Oncol. Biol. Phys. 2001, 50 (3),809– 820.
    OpenUrlCrossRefPubMedWeb of Science
  38. 38.↵
    1. Fernández-Carballido A.,
    2. Puebla P.,
    3. Herrero-Vanrell R.,
    4. Pastoriza P.
    Radiosterilization of indomethacin PLGA/PEG-derivative microspheres: protective effects of low temperature during gamma-irradiation. Int. J. Pharm. 2006, 313 (1–2),129– 135.
    OpenUrlPubMed
  39. 39.↵
    1. Fernández-Carballido A.,
    2. Herrero-Vanrell R.,
    3. Molina-Martinez I. T.,
    4. Pastoriza P.
    Sterilized ibuprofen-loaded poly(D,L-lactide-co-glycolide) microspheres for intra-articular administration: effect of gamma-irradiation and storage. J. Microencapsul. 2004, 21 (6),653– 665.
    OpenUrlPubMed
  40. 40.↵
    1. Çolak S.,
    2. Korkmaz M.
    Investigation of radiosterilization and dosimetric features of sulfacetamide sodium. J. Pharm. Biomed. Anal. 2004, 36 (4),791– 798.
    OpenUrlPubMed
  41. 41.↵
    1. Carrascosa C.,
    2. Espejo L.,
    3. Torrado S.,
    4. Torrado J. J.
    Effect of gamma-sterilization process on PLGA microspheres loaded with insulin-like growth factor-I (IGF-I). J. Biomater. Appl. 2003, 18 (2),95– 108.
    OpenUrlAbstract/FREE Full Text
  42. 42.↵
    1. Montanari L.,
    2. Cilurzo F.,
    3. Selmin F.,
    4. Conti B.,
    5. Genta I.,
    6. Poletti G.,
    7. Orsini F.,
    8. Valvo L.
    Poly(lactide-co-glycolide) microspheres containing bupivacaine: comparison between gamma and beta irradiation effects. J. Control. Release 2003, 90 (3),281– 290.
    OpenUrlPubMed
  43. 43.↵
    1. Oliveira A. L.,
    2. Mano J. F.,
    3. Román J. S.,
    4. Reis R. L.
    Study of the influence of beta-radiation on the properties and mineralization of different starch-based biomaterials. J. Biomed. Mater. Res. B Appl. Biomater. 2005, 74 (1),560– 569.
    OpenUrlPubMed
  44. 44.↵
    1. Powell D. B.
    Manual on Radiation Sterilization of Medical and Biological Materials, Technical Reports Series No.149; IAEA: Vienna, 1973; pp 111– 129.
  45. 45.↵
    1. Soliman E. A.,
    2. Mohy Eldin M. S.,
    3. Furuta M.
    Biodegradable zein-based films: influence of gamma-irradiation on structural and functional properties. J. Agric. Food Chem. 2009, 57 (6),2529– 2535.
    OpenUrlPubMed
  46. 46.↵
    1. Kausch H.
    Radiation Effects on Polymers for Biological Use; Kausch H. Ed.; Advances in Polymer Science 162; Springer-Verlag: Berlin, 2003; pp 63– 93.
  47. 47.↵
    1. Saçak M.
    Polimer Kimyası; Gazi Kitapevi: Ankara, Türkiye, 2002; pp 228– 299.
  48. 48.↵
    1. Sawyer L. C.,
    2. Grubb D. T.,
    3. Meyers G. F.
    Polymer Microscopy, 3rd ed.; Springer: New York, 2008; pp 1– 25.
  49. 49.↵
    1. Matthews I. P.,
    2. Gibson C.,
    3. Samuel A. H.
    Sterilisation of implantable devices. Clin. Mater. 1994, 15 (3),191– 215.
    OpenUrlCrossRefPubMed
  50. 50.↵
    1. Denizli K. F.
    Medikal cihaz üretiminde kullanılan polimerlere radyasyon etkisi. Türkiye Atom Enerjisi Kurumu (TAEK), Ankara Nükleer Tarım ve Hayvancılık Araştırma Merkezi Gıda Işınlama ve Sterilizasyon Bölümü, Endüstride Radyasyonla Sterilizasyon Kursu, Sarayköy, Ankara, 21– 25 October 2002.
  51. 51.↵
    1. Sobhi H.,
    2. Matthews M. E.,
    3. Grandy B.,
    4. Masnovi J.,
    5. Riga A. T.
    Selecting polymers for medical devices based on thermal analytical methods. J. Therm. Anal. Calorim. 2008, 93 (2),535– 539.
    OpenUrl
  52. 52.↵
    Introduction to Biopolymers. http://www.burdica.com/Medical-Biopolymers.html.
  53. 53.↵
    1. Fried J. R.
    Polymer Science and Technology, 2nd ed.; Prentice Hall Professional Technical References (PTR), Pearson Education, Inc.: Upper Saddle River, NJ, 2003; pp 1– 22., 153–205, 263–282, 353–388, 518–521.
  54. 54.↵
    1. Bruck S. D.,
    2. Mueller E. P.
    Radiation sterilization of polymeric implant materials. J. Biomed. Mater. Res. 1988, A2 Suppl., 133– 144.
  55. 55.↵
    1. An Y. H.,
    2. Alvi F. I.,
    3. Kang Q.,
    4. Laberge M.,
    5. Drews M. J.,
    6. Zhang J.,
    7. Matthews M. A.,
    8. Arciola C. R.
    Effects of sterilization on implant mechanical property and biocompatibility. Int. J. Artif. Organs 2005, 28 (11),1126– 1137.
    OpenUrlPubMed
  56. 56.↵
    1. Bertrand O. F.,
    2. Sipehia R.,
    3. Mongrain R.,
    4. Rodés J.,
    5. Tardif J. C.,
    6. Bilodeau L.,
    7. Côté G.,
    8. Bourassa M. G.
    Biocompatibility aspects of new stent technology. J. Am. Coll. Cardiol. 1998, 32 (3),562– 571.
    OpenUrlCrossRefPubMedWeb of Science
  57. 57.↵
    1. Vasita R.,
    2. Shanmugam I. K.,
    3. Katt D. S.
    Improved biomaterials for tissue engineering applications: surface modification of polymers. Curr. Top. Med. Chem. 2008, 8 (4),341– 353.
    OpenUrlCrossRefPubMedWeb of Science
  58. 58.↵
    1. Reichmanis E.,
    2. Frank C. W.,
    3. O'Donnell J. H.,
    4. Hill D. J. T.
    Irradiation of Polymeric Materials; American Chemical Society: Washington, DC, 1993; pp 1– 8.
  59. 59.↵
    Tissue Engineering: The Nuts and Bolts. http://www.medicaldevice-network.com/features/feature386/.
  60. 60.↵
    1. Carvalho F. G.,
    2. Fucio S. B.,
    3. Pascon F. M.,
    4. Kantovitz K. R.,
    5. Correr-Sobrinho L.,
    6. Puppin-Rontani R. M.
    Effect of gamma irradiation on fluoride release and antibacterial activity of resin dental materials. Braz. Dent. J. 2009, 20 (2),122– 126.
    OpenUrlPubMed
  61. 61.↵
    1. DiCicco M.,
    2. Compton R.,
    3. Duong T.,
    4. Jansen-Varnum S. A.
    Electron paramagnetic resonance analyses of surface radical chemistries of gamma-sterilized orthopedic materials: Implications pointing to cytotoxicity via wear debris-induced inflammation. J. Biomed. Mater. Res. B Appl. Biomater. 2005, 75 (1),6– 17.
    OpenUrlPubMed
  62. 62.↵
    1. Mcgovern T. F.,
    2. Ammeen D. J.,
    3. Collier J. P.,
    4. Currier B. H.,
    5. Engh G. A.
    Rapid polyethylene failure of unicondylar tibial components sterilized with gamma irradiation in air and implanted after a long shelf life. J. Bone Joint Surg. Am. 2002, 84-A (6), 901– 906.
    OpenUrlPubMed
  63. 63.↵
    1. Briganti E.,
    2. Al Kayal T.,
    3. Kull S.,
    4. Losi P.,
    5. Spiller D.,
    6. Tonlorenzi S.,
    7. Berti D.,
    8. Soldani G.
    The effect of gamma irradiation on physical-mechanical properties and cytotoxicity of polyurethane-polydimethylsiloxane microfibrillar vascular grafts. J. Mater. Sci. Mater. Med. 2010, 21 (4),1311– 1319.
    OpenUrlCrossRefPubMed
  64. 64.↵
    1. Bruck S. D.
    Long-term stability of intraocular lenses: literature review, assessment, and testing protocol. J. Long Term Eff. Med. Implants 1993, 3 (4),333– 350.
    OpenUrlPubMed
  65. 65.↵
    1. Denizli K. F.
    Test Yöntemleri-Radyasyonun Malzemeye Etkisinin Ölçülmesi ve Değerlendirilmesi. Endüstride Radyasyonla Sterilizasyonda Kalite Kontrolü ve Kalite Temini Uygulamaları Kursu, Türkiye Atom Enerjisi Kurumu Ankara Nükleer Araştırma ve Eğitim Merkezi, Gama Işınlama Tesisi, Sarayköy, Ankara, 20– 24 November 1995.
  66. 66.↵
    1. Denizli K. F.
    İyonlaştırıcı ışınlarla ışınlanmış polikarbonatın biyouyumluluğu. PhD Dissertation, Hacettepe University, Ankara, Turkey, 1999.
  67. 67.↵
    1. Ohki Y.
    Radiation effects on polymers. IEEE Transactions on Electrical Insulation 1986, 21 (6),919– 922.
    OpenUrl
  68. 68.↵
    1. Bennet J.
    Material Considerations: Irradiation Processing. Sterigenics, 1– 4. Accessible at http://www.sterigenics.com/services/medical_sterilization/contract_sterilization/material_consideration__irradiation_processing.pdf.
  69. 69.↵
    1. Hegazy E. A.,
    2. Abdel-Rehim H.,
    3. Diaa D. A.,
    4. El-Barbary A.
    Controlling of Degradation Effects in Radiation Processing of Polymers, IAEA-TECDOC-1617; IAEA: Vienna, 2009; pp 67– 84.
  70. 70.↵
    1. Chapiro A.
    Radiation Chemistry of Polymeric Systems, High Polymers; Wiley-Interscience: New York, 1962; pp 64– 75.
  71. 71.↵
    1. Rabek J. F.
    Experimental Methods in Polymer Chemistry; John Wiley: New York, 1980; p 527.
  72. 72.↵
    1. Simha R.,
    2. Wall L.
    Mechanism of high energy radiation effects in polymers. J. Phys. Chem. 1957, 61 (4),425– 430.
    OpenUrl
  73. 73.↵
    1. Zündorf J,
    2. Kremer S.,
    3. Grüger T.
    Formation of hydrogen fluoride by gamma and beta sterilisation in medical devices containing perfluoroheptane. Toxicology 2008, 243 (3),284– 293.
    OpenUrlPubMed
  74. 74.↵
    1. Kanjickal D.,
    2. Lopina S.,
    3. Evancho-Chapman M. M.,
    4. Schmidt S.,
    5. Donovan D.
    Effects of sterilization on poly(ethylene glycol) hydrogels. J. Biomed. Mater. Res. A 2008, 87 (3),608– 617.
    OpenUrlPubMed
  75. 75.↵
    1. Jayabalan M.,
    2. Lizymol P. P.
    Effect of γ-radiation sterilization on the stability of polyurethane potting compounds based on castor oil/SMDI and caprolactone polyol/SMDI, used for hollow fibre haemodialyzer. Bull. Mater. Sci. 1997, 20 (5),727– 735.
    OpenUrl
  76. 76.↵
    1. Hemmerich K. J.
    Polymer Materials Selection for Radiation-Sterilized Products. MDDI, 2000. Accessible at http://www.mddionline.com/article/polymer-materials-selection-radiation-sterilized-products.
  77. 77.↵
    1. Killian P.,
    2. Rabe R.,
    3. Blackmore J.
    Effect of gamma sterilization on select TPE materials, RTP Company Imagineering Plastics, 1– 12., 2008. (http://medicaldesign.com/Whitepapers/TPE_Gamma_Sterilization_White_Paper.pdf).
  78. 78.↵
    1. Fengmei L.,
    2. Dianhua C.
    Effect of radiation on structure and properties of material made from oxpericardium. Radiat. Phys. Chem. 1998, 52 (1–6),323– 326.
    OpenUrl
  79. 79.↵
    1. Czvikovszky T.
    Degradation effects in polymers. In Advances in Radiation Chemistry of Polymers, IAEA-TECDOC-1420; IAEA: Vienna, 2003; pp 91– 102.
  80. 80.↵
    1. Kantoğlu Ö
    Alternatif Sterilizasyon Yöntemlerinin Malzemeye Etkisi. Türkiye Atom Enerjisi Kurumu (TAEK), Ankara Nükleer Tarım ve Hayvancılık Araştırma Merkezi Gıda Işınlama ve Sterilizasyon Bölümü, Endüstride Radyasyonla Sterilizasyon Kursu, Sarayköy, Ankara, 21– 25 October 2002.
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 66 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 66, Issue 2
March/April 2012
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Effect of Radiation on a Variety of Pharmaceuticals and Materials Containing Polymers
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
The Effect of Radiation on a Variety of Pharmaceuticals and Materials Containing Polymers
Mine Silindir, Yekta Özer
PDA Journal of Pharmaceutical Science and Technology Mar 2012, 66 (2) 184-199; DOI: 10.5731/pdajpst.2012.00774

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The Effect of Radiation on a Variety of Pharmaceuticals and Materials Containing Polymers
Mine Silindir, Yekta Özer
PDA Journal of Pharmaceutical Science and Technology Mar 2012, 66 (2) 184-199; DOI: 10.5731/pdajpst.2012.00774
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Importance of Radiosterilization
    • The Effects of Radiation on Pharmaceuticals
    • Polymers Used for Medical Devices
    • Physical and Chemical Methods for Preventing the Harmful Effects of Radiation
    • Conclusion
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • A Small-scale Model to Assess the Risk of Leachables from Single-use Bioprocess Containers through Protein Quality Characterization
  • Gamma Sterilization of Pharmaceuticals--A Review of the Irradiation of Excipients, Active Pharmaceutical Ingredients, and Final Drug Product Formulations
  • Google Scholar

More in this TOC Section

  • The Role of Microbiologists in Drug Product Development
  • A Risk Assessment and Risk-Based Approach Review of Pre-Use/Post-Sterilization Integrity Testing (PUPSIT)
  • Recommendations for Artificial Intelligence Application in Continued Process Verification: A Journey Toward the Challenges and Benefits of AI in the Biopharmaceutical Industry
Show more Review

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire