Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleResearch

Evaluation of the General Solution Compatibility of Polymer Materials Used in Medical Devices such as Syringes

Dennis Jenke, Alex Odufu, Tom Couch, Molly Chacko, Steve Strathmann and Eric Edgcomb
PDA Journal of Pharmaceutical Science and Technology July 2012, 66 (4) 286-306; DOI: https://doi.org/10.5731/pdajpst.2012.00869
Dennis Jenke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: dennis_jenke@baxter.com
Alex Odufu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tom Couch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Molly Chacko
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steve Strathmann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric Edgcomb
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Moorhatch P.,
    2. Chiou W. L.
    Interaction between drugs and plastic intravenous fluid bag. I. Sorption studies on 17 drugs. Am. J. Hosp. Pharm. 1977, 31, 72– 78.
    OpenUrl
  2. 2.↵
    1. Illum I.,
    2. Bundgaard H.
    Sorption of drugs by plastic infusion bags. Int. J. Pharm. 1982, 10 (4), 339– 351.
    OpenUrlCrossRefWeb of Science
  3. 3.↵
    1. Sanchez I. C.,
    2. Chang S. S.,
    3. Smith L. E.
    Migration models for polymer additives. Poly. News 1980, 6 (6), 249– 256.
    OpenUrl
  4. 4.↵
    1. Pitt C. G.,
    2. Bao Y. T.,
    3. Andrady A. L.,
    4. Samuel P. N. K.
    The correlation of polymer-water and octanol-water partition coefficients: estimation of drug solubility in polymers. Int. J. Pharm. 1988, 45 (1–2), 1– 11.
    OpenUrl
  5. 5.↵
    1. Jordon D. O.,
    2. Pollack A. E.
    The permeation of organic solutes through polyethylene membranes. II. Effect of concentration, temperature and other variables. Aust. J. Pharm. Sci. 1972, N51, 82– 87.
    OpenUrl
  6. 6.↵
    1. Nasim K.,
    2. Meyer M. C.,
    3. Aution J.
    Permeation of aromatic organic compounds from aqueous solutions through polyethylene. J. Pharm. Sci. 1976, 61 (11), 1775– 1780.
    OpenUrl
  7. 7.↵
    1. Serota D. G.,
    2. Meyer M. C.,
    3. Autian J.
    Effect of structure on permeability of substituted anilines from aqueous solutions through polyethylene. J. Pharm, Sci. 1972, 61 (3), 416– 419.
    OpenUrlPubMed
  8. 8.↵
    1. Jenke D. R.,
    2. Brennan J.,
    3. Doty M.,
    4. Poss M.
    Use of binary ethanol/water model solutions to mimic the interaction between a plastic material and pharmaceutical formulations. J. Appl. Poly. Sci. 2003, 89 (4), 1049– 1057.
    OpenUrl
  9. 9.↵
    1. Hayward D. S.,
    2. Kenley R. A.,
    3. Jenke D. R.
    Interaction between polymer containers and parenteral solutions: the correlation of equilibrium constants for polymer-water partitioning with octanol-water partition coefficients. Int. J. Pharm. 1990, 59 (3), 245– 253.
    OpenUrl
  10. 10.↵
    1. Jenke D. R.,
    2. Kenley R. A.,
    3. Hayward D. S.
    Interactions between polymeric containers and their contained solution: Modeling of polymer-water solute partitioning via coupled solvent-water partition coefficients. J. Appl. Poly. Sci. 1991, 43 (8), 1475– 1482.
    OpenUrl
  11. 11.↵
    1. Jenke D. R.
    Evaluation of various solvent systems for modeling solute sorption by plasticized polyvinyl chloride materials. J. Pharm. Sci. 1993, 82 (6), 617– 621.
    OpenUrlPubMed
  12. 12.↵
    1. Jenke D. R.
    Drug binding by reservoirs in elastomeric infusion devices. Pharm. Res. 1994, 11 (7), 984– 989.
    OpenUrlPubMed
  13. 13.↵
    1. Jenke D. R.,
    2. Chess E. K.,
    3. Jakubowski G.
    Modeling of the leachables impact on the engineering of parenteral product container systems. Int. J. Pharm. 1994, 108 (1), 1– 9.
    OpenUrl
  14. 14.↵
    1. Ulsaker G. A.,
    2. Hoem R. M.
    Determination by gas chromatography-single-ion monitoring mass spectrometry of phthalate contaiminants in intravenous solutions stored in PVC containers. Analyst 1979, 103, 1080– 1083.
    OpenUrl
  15. 15.↵
    1. Arbin A.,
    2. Jacobsson S.,
    3. Hanninen K.,
    4. Hagman A.,
    5. Ostelius J.
    Studies on the contamination of intravenous solutions from PVC-bags with dynamic headspace GC-MS and LC-diode array techniques. Int. J. Pharm. 1986, 28 (2–3), 211– 218.
    OpenUrl
  16. 16.↵
    1. Snell R. P.
    Solid-phase extraction and liquid chromatographic determination of monophthalates and phthalide extracted from solution administration sets. JAOAC 1993, 76 (3), 531– 534.
    OpenUrl
  17. 17.↵
    1. Goydan R.,
    2. Schwope A. D.,
    3. Redi R. C.,
    4. Cramer G.
    High-temperature migration of antioxidants from polyolefins. Food Additives and Contamination 1990, 7 (3), 323– 337.
    OpenUrl
  18. 18.↵
    1. Sarbach C.,
    2. Yagoubi N.,
    3. Sauzieres J.,
    4. Renaux C.,
    5. Ferrier D.,
    6. Postaire E.
    Migration of impurities from a multi-layer plastic container into a parenteral infusion solution. Int. J. Pharm. 1996, 140 (2), 169– 174.
    OpenUrl
  19. 19.↵
    1. Kim H.,
    2. Gilbert S. G.,
    3. Johnson J. B.
    Determination of potential migrants from commercial amber polyethylene terephthalate bottle wall. Pharm. Res. 1990, 7 (2), 176– 179.
    OpenUrlPubMed
  20. 20.↵
    1. Danielson D. M.,
    2. Oxborrow G. S.,
    3. Placencia A. M.
    Chemical leaching of rubber stoppers into parenteral solutions. J. Parent. Sci. Technol. 1983, 37 (3), 89– 92.
    OpenUrl
  21. 21.↵
    1. Reif A. W.,
    2. Solkner P.,
    3. Rupp J.
    Analysis and evaluation of filter cartridge extractables for validation in pharmaceutical downstream processing. PDA J. Pharm. Sci. Technol. 1996, 50 (6), 399– 410.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Arbin A.,
    2. Ostelius J.,
    3. Callmer K.,
    4. Sroka J.,
    5. Hanninen K.,
    6. Axelsson S.
    Migration of chemicals from soft PVC bags into intravenous solutions. Acta Pharm. Seuc. 1983, Suppl. #3, 20.
  23. 23.↵
    1. Airaudo C. B.,
    2. Gayte-Sorbier A.,
    3. Momburg R.,
    4. Laurent P.
    Thin-layer chromatographic characterization of benzothiazole derivatives and B-sitosterol leached by disposable syringes. J. Chromatogr. 1986, 354, 341– 354.
    OpenUrlPubMed
  24. 24.
    1. Jenke D.
    Extractable/leachable substances from plastic materials used as pharmaceutical product containers/devices. PDA J. Pharm. Sci. Technol. 2002, 56 (6), 332– 371.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 66 (4)
PDA Journal of Pharmaceutical Science and Technology
Vol. 66, Issue 4
July/August 2012
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Evaluation of the General Solution Compatibility of Polymer Materials Used in Medical Devices such as Syringes
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
5 + 8 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Evaluation of the General Solution Compatibility of Polymer Materials Used in Medical Devices such as Syringes
Dennis Jenke, Alex Odufu, Tom Couch, Molly Chacko, Steve Strathmann, Eric Edgcomb
PDA Journal of Pharmaceutical Science and Technology Jul 2012, 66 (4) 286-306; DOI: 10.5731/pdajpst.2012.00869

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Evaluation of the General Solution Compatibility of Polymer Materials Used in Medical Devices such as Syringes
Dennis Jenke, Alex Odufu, Tom Couch, Molly Chacko, Steve Strathmann, Eric Edgcomb
PDA Journal of Pharmaceutical Science and Technology Jul 2012, 66 (4) 286-306; DOI: 10.5731/pdajpst.2012.00869
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results and Discussion
    • Conclusion
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Science- and risk-based strategy to qualify prefillable autoclavable syringes as primary packaging material
  • Low Leachable Container System Consisting of a Polymer-Based Syringe with Chlorinated Isoprene Isobutene Rubber Plunger Stopper
  • Materials in Manufacturing and Packaging Systems as Sources of Elemental Impurities in Packaged Drug Products: A Literature Review
  • Extractables Characterization for Five Materials of Construction Representative of Packaging Systems Used for Parenteral and Ophthalmic Drug Products
  • Google Scholar

More in this TOC Section

  • Quantitative and Qualitative Evaluation of Microorganism Profile Identified in Bioburden Analysis in a Biopharmaceutical Facility in Brazil: Criteria for Classification and Management of Results
  • Evaluation of Extreme Depyrogenation Conditions on the Surface Hydrolytic Resistance of Glass Containers for Pharmaceutical Use
  • A Holistic Approach for Filling Volume Variability Evaluation and Control with Statistical Tool
Show more Research

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire