Research ArticleConference Proceeding - Article
Emerging Unit Operations (Session III): Hydroxyapatite, Mixed-Mode, and Adsorptive Membrane Chromatography; UV-C Inactivation; Chemical Precipitation
Brian Hubbard and David Roush
PDA Journal of Pharmaceutical Science and Technology January 2014, 68 (1) 51-65; DOI: https://doi.org/10.5731/pdajpst.2014.00966
Brian Hubbard
1Amgen, Inc. Thousand Oaks, CA; and
Ph.D.David Roush
2Merck Sharp and Dohme, Kenilworth, NJ
Ph.D.
References
In This Issue
PDA Journal of Pharmaceutical Science and Technology
Vol. 68, Issue 1
January/February 2014
Emerging Unit Operations (Session III): Hydroxyapatite, Mixed-Mode, and Adsorptive Membrane Chromatography; UV-C Inactivation; Chemical Precipitation
Brian Hubbard, David Roush
PDA Journal of Pharmaceutical Science and Technology Jan 2014, 68 (1) 51-65; DOI: 10.5731/pdajpst.2014.00966
Jump to section
- Article
- Hydroxyapatite and Mixed-Mode Chromatography (HA/MM) Background
- Ceramic Hydroxyapatite Chromatography in a Monoclonal Antibody (mAb) Platform Purification Process: Virus Clearance (Eileen Wilson, GlaxoSmithKline)
- Defining Robust Operating Ranges for Mixed-Mode Chromatography in a mAb Platform Process for Reproducible Viral Clearance (D. Vacante, Johnson & Johnson)
- Virus Clearance on Capto Adhere® (Sherrie Curtis; Genentech, a Member of the Roche Group)
- Key Parameters for MuLV Removal by Capto Adhere® Chromatography (Lisa Connell-Crowley, Amgen)
- Adsorptive Membrane Chromatography Background
- Determination of the Effect of Impurities on Viral Log Reduction across Q Membrane (Judy Glynn, Paul Mensah, and Kristin Thomas; Pfizer)
- Challenges in Demonstrating Viral Clearance for AEX Membrane Steps (Scott A. Tobler, Morgan Barth, and David Roush; Merck Sharp and Dohme)
- Case Studies in AEX Filtration for the Removal of Viruses (Michael Clark; Abbott Bioresearch Center, Worcester, MA)
- MC Summary
- UV-C Inactivation and Chemical Precipitation (UV/CP) Background
- Evaluation and Development of UV-C Viral Inactivation Processing Methods (Joe Shultz, Amgen)
- Precipitation of MuLV by Caprylate (Lisa Connell-Crowley, Amgen)
- References
- Figures & Data
- References
- Info & Metrics
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