Article Figures & Data
Figures
- Figure 1
Hydrolytic testing results (USP <660> Surface Glass Test, EP3.2.1 Test A) of ion-exchanged alkali aluminosilicate 3 mL vials and three different alkali borosilicate 3 mL vials. Error bars indicate typical measurement variation in a control population.
- Figure 2
Estimated loss of boron and alkali species from a Type 1B alkali borosilicate glass and the alkali aluminosilicate glass over a range of temperature in a stoichiometric flame. Plot shows the elemental fraction of boron and alkali in the gas phase at equilibrium.
- Figure 3
Plot of ICP-MS solution concentrations for metals extracted from alkali borosilicate and alkali aluminosilicate glass vials into WFI after autoclaving and 8 weeks of storage at 50 °C. Error bars represent the pooled standard deviation.
- Figure 4
Product degradation kinetics under accelerated storage conditions for one stability-indicating assay when stored in standard alkali borosilicate vials (Historical Mean) and alkali aluminosilicate vials.
Tables
- Table II
Thermal, Physical, Mechanical, and Optical Properties and Associated Test Methods of a Few Alkali Borosilicate Glasses and the Alkali Aluminosilicate Glass
units TEST METHOD Type 1B Type 1A Aluminosilicate Borosilicate A Borosilicate B Borosilicate C Borosilicate H Strain Point (1014.5 P) °C ASTM C336-71/2010 525 530 537 525 556 Anneal Point (1013 P) °C ASTM C336-71/2010 560 565 576 560 608 Softening Point (107.6 P) °C ASTM C338-93/2008 780 785 767 825 870 Working Point (104 P) °C ASTM C965-96/2012 1164 1160 1260 1292 (0–300°C) Thermal Expansion 10−7 K−1 ASTM E228-11 52 49 53 33 69 Density g/cm3 ASTM C693-93/2008 2.34 2.34 2.41 2.23 2.39 Refractive Index @ 589nm various methods 1.49 1.492 1.473 1.493 Stress-Optic Coefficient 10−6 mm2.N−1 ASTM C770-98/2008 3.4 4.0 3.05 Young's modulus GPa ASTM C623-92/2010 73 63 71 Poisson's ratio - ASTM C623-92/2010 0.2 0.2 0.2 - Table IV
Average ICP-MS Concentrations for Vials Autoclaved and Stored in Water for Injection (WFI) at 25°C for 8 Weeks
Values shown in italics indicate the detection limit of the ICP-MS method; in those cases, standard deviation values are not applicable. Sn is not included in the table because it was not detected in any of the samples at any temperature (detection limit for Sn is 0.01 ppm).
ug/g Aluminosilicate Borosilicate A Vial A Borosilicate B Vial B Borosilicate B Vial E Borosilicate B Vial F Mean Pooled SD Mean Pooled SD Mean Pooled SD Mean Pooled SD Mean Pooled SD Al 0.07 0.02 0.71 0.13 0.12 0.01 0.03 0.01 0.07 0.01 B 0.20 1.82 0.12 0.20 0.20 0.20 Ca 0.16 0.06 0.20 0.03 0.12 0.06 0.08 0.02 0.19 0.05 K 1.13 0.05 0.45 0.02 0.05 0.07 0.01 0.06 0.02 Mg 0.10 0.01 0.10 0.00 0.01 0.01 0.08 0.00 Na 0.70 0.04 3.18 0.12 3.79 0.06 2.48 0.05 1.20 0.04 Si 1.21 0.11 8.61 0.43 1.75 0.15 0.37 0.01 0.95 0.16
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