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Research ArticleCONFERENCE PROCEEDING

Modeling an Approach To Define Sensitivity of Viral Detection in Sample Matrices—Examples with Microarray Readout

Szi Fei Feng, Crystal Jaing, James B. Thissen, Christopher Wang and Paul Duncan
PDA Journal of Pharmaceutical Science and Technology November 2014, 68 (6) 589-594; DOI: https://doi.org/10.5731/pdajpst.2014.01011
Szi Fei Feng
1Merck Research Laboratories, Sumneytown Pike, West Point, PA, USA; and
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  • For correspondence: szifei_feng@merck.com
Crystal Jaing
2Physical & Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA
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James B. Thissen
2Physical & Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA
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Christopher Wang
1Merck Research Laboratories, Sumneytown Pike, West Point, PA, USA; and
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Paul Duncan
1Merck Research Laboratories, Sumneytown Pike, West Point, PA, USA; and
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Article Information

vol. 68 no. 6 589-594
DOI 
https://doi.org/10.5731/pdajpst.2014.01011
PubMed 
25475633

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 4, 2014.

Copyright & Usage 
© PDA, Inc. 2014

Author Information

  1. Szi Fei Feng1,*,
  2. Crystal Jaing2,
  3. James B. Thissen2,
  4. Christopher Wang1 and
  5. Paul Duncan1
  1. 1Merck Research Laboratories, Sumneytown Pike, West Point, PA, USA; and
  2. 2Physical & Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA
  1. ↵*Corresponding Author: Szi Fei Feng, Merck Research Laboratories, WP17-101, Sumneytown Pike, West Point, PA, USA 19486. Telehone: 215-652-8359; e-mail: szifei_feng{at}merck.com
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PDA Journal of Pharmaceutical Science and Technology: 68 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 68, Issue 6
November/December 2014
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Modeling an Approach To Define Sensitivity of Viral Detection in Sample Matrices—Examples with Microarray Readout
Szi Fei Feng, Crystal Jaing, James B. Thissen, Christopher Wang, Paul Duncan
PDA Journal of Pharmaceutical Science and Technology Nov 2014, 68 (6) 589-594; DOI: 10.5731/pdajpst.2014.01011

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Modeling an Approach To Define Sensitivity of Viral Detection in Sample Matrices—Examples with Microarray Readout
Szi Fei Feng, Crystal Jaing, James B. Thissen, Christopher Wang, Paul Duncan
PDA Journal of Pharmaceutical Science and Technology Nov 2014, 68 (6) 589-594; DOI: 10.5731/pdajpst.2014.01011
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  • Article
    • Abstract
    • Introduction
    • Selection of Viruses for Spike Recovery Studies
    • Selection of Sample Matrices
    • Sample Preparation Workflows
    • Microarray Detection
    • Summary
    • Conflict of Interest Declaration
    • Footnotes
    • References
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More in this TOC Section

  • Proceedings of the 2017 Viral Clearance Symposium, Session 4: Submission Strategies
  • Proceedings of the 2017 Viral Clearance Symposium Session 5: Facility Risk Mitigation
  • Proceedings of the 2017 Viral Clearance Symposium: Conclusion
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Keywords

  • virus detection
  • Sensitivity
  • Spike recovery
  • Microarray

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