Detection of Adventitious Agents Using Next-Generation Sequencing

Brenda Richards; Sherry Cao; Mark Plavsic; Robert Pomponio; Claire Davies; Robert Mattaliano; Stephen Madden; Katherine Klinger; Adam Palermo

doi:10.5731/pdajpst.2014.01025

Research ArticleCONFERENCE PROCEEDING

Detection of Adventitious Agents Using Next-Generation Sequencing

Brenda Richards, Sherry Cao, Mark Plavsic, Robert Pomponio, Claire Davies, Robert Mattaliano, Stephen Madden, Katherine Klinger and Adam Palermo

PDA Journal of Pharmaceutical Science and Technology November 2014, 68 (6) 651-660; DOI: https://doi.org/10.5731/pdajpst.2014.01025

Brenda Richards

aFunctional Genomics & Science Computing;

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For correspondence: brenda.richards@genzyme.com

Sherry Cao

aFunctional Genomics & Science Computing;

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Mark Plavsic

bProcess Engineering Development;

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Robert Pomponio

cClinical Assay Development;

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Claire Davies

dAnalytical Development;

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Robert Mattaliano

eBiologics Research & Development, Genzyme, A Sanofi Company, Framingham, MA, USA

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Stephen Madden

aFunctional Genomics & Science Computing;

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Katherine Klinger

aFunctional Genomics & Science Computing;

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Adam Palermo

aFunctional Genomics & Science Computing;

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Article Information

vol. 68 no. 6 651-660

DOI

https://doi.org/10.5731/pdajpst.2014.01025

PubMed

25475640

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online December 4, 2014.

Author Information

Brenda Richardsa,*,
Sherry Caoa,
Mark Plavsicb,
Robert Pomponioc,
Claire Daviesd,
Robert Mattalianoe,
Stephen Maddena,
Katherine Klingera and
Adam Palermoa

^aFunctional Genomics & Science Computing;
^bProcess Engineering Development;
^cClinical Assay Development;
^dAnalytical Development;
^eBiologics Research & Development, Genzyme, A Sanofi Company, Framingham, MA, USA

↵*Corresponding Author: Brenda Richards, Genzyme, A Sanofi Company, 49 New York Avenue, Framingham, MA, USA 01701. Telephone: 508-270-2226; e-mail: brenda.richards{at}genzyme.com

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Detection of Adventitious Agents Using Next-Generation Sequencing

Brenda Richards, Sherry Cao, Mark Plavsic, Robert Pomponio, Claire Davies, Robert Mattaliano, Stephen Madden, Katherine Klinger, Adam Palermo

PDA Journal of Pharmaceutical Science and Technology Nov 2014, 68 (6) 651-660; DOI: 10.5731/pdajpst.2014.01025

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Detection of Adventitious Agents Using Next-Generation Sequencing

Brenda Richards, Sherry Cao, Mark Plavsic, Robert Pomponio, Claire Davies, Robert Mattaliano, Stephen Madden, Katherine Klinger, Adam Palermo

PDA Journal of Pharmaceutical Science and Technology Nov 2014, 68 (6) 651-660; DOI: 10.5731/pdajpst.2014.01025

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k-mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing

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Keywords

Next-generation sequencing
Limit of detection
Adventitious agents
Library construction
Biosurveillance

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