Research ArticleProceedings of the 2013 Viral Clearance Symposium
Viral Clearance of Traditional Unit Operations: Virus-Retentive Filtration
Qi Chen and Dayue Chen
PDA Journal of Pharmaceutical Science and Technology January 2015, 69 (1) 142-153; DOI: https://doi.org/10.5731/pdajpst.2015.01038
Qi Chen
1Genentech, a Member of the Roche Group; Process Virology, 1 DNA Way, Mailstop 10, South San Francisco, CA 94080;
Dayue Chen
2Bioproduct Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285

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In This Issue
PDA Journal of Pharmaceutical Science and Technology
Vol. 69, Issue 1
January/February 2015
Viral Clearance of Traditional Unit Operations: Virus-Retentive Filtration
Qi Chen, Dayue Chen
PDA Journal of Pharmaceutical Science and Technology Jan 2015, 69 (1) 142-153; DOI: 10.5731/pdajpst.2015.01038
Jump to section
- Article
- Introduction
- Proposed Operation and Validation of Multiple Viral Filtration Cycles within a Harvest Lot (Eva Gefroh, and Megan McClure; Amgen)
- Virus-Retentive Filtration (Thomas Kreil; Global Pathogen Safety—Baxter BioScience)
- Introduction of an Alternate Viral Filter to a Commercial Process and Optimization of Scale-down Filter Capacity (Philippe de Vilmorin; Biogen Idec)
- Parvovirus Clearance on a Virus-Retentive Filter—Consideration of Log Reduction and Virus Breakthrough in Determining Virus Load Challenge (Eileen Wilson; GlaxoSmithKline)
- Low Pressure and High Membrane Load Lead to Virus Breakthrough in Virus Removal Filtration of a MAb (Susan Liu; Janssen Research and Development)
- Effect of pH, Conductivity, Pressure Release on Parvovirus Clearance (Sean O'Donnell, Adith Venkiteshwaran, and Dayue Chen; Eli Lilly and Company)
- Impact of Using High-Purity Virus Spikes on the Apparent Breakthrough of MMV during Viral-Retentive Filtration Evaluations and Maintaining Virus Retention during Depressurisation Events (James Berrie; Lonza)
- Prediction of Viral Filtration (VF) Performance of MAbs via Biophysical Analysis (William Rayfield, David Roush, Jason Cheung, Shehab Barakat, and Nihal Tugcu; Merck Research Laboratories)
- Mechanistic Failure Mode Resolution and Comparison of Parvovirus-Retentive Filters (Daniel LaCasse, Pfizer; and Kurt Brorson, Center for Drug Evaluation and Research, U.S. Food and Drug Administration)
- Impact of Pressure and Pausing on Virus-Retentive Riltration (John Mattila; Regeneron)
- Summary
- References
- Figures & Data
- References
- Info & Metrics
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