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Research ArticleResearch

A Strategy for the Prevention of Protein Oxidation by Drug Product in Polymer-Based Syringes

Koji Nakamura, Yoshihiko Abe, Hideaki Kiminami, Arisa Yamashita, Kazuhiro Iwasaki, Shigeru Suzuki, Keisuke Yoshino, William Dierick and Kevin Constable
PDA Journal of Pharmaceutical Science and Technology January 2015, 69 (1) 88-95; DOI: https://doi.org/10.5731/pdajpst.2015.01009
Koji Nakamura
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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  • For correspondence: Kouji2Nakamura@terumo.co.jp
Yoshihiko Abe
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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Hideaki Kiminami
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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Arisa Yamashita
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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Kazuhiro Iwasaki
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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Shigeru Suzuki
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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Keisuke Yoshino
1Terumo Corporation, R&D Center, Kanagawa, Japan;
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William Dierick
2Terumo Europe NV, Leuven, Belgium; and
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Kevin Constable
3Terumo Medical Corporation, Somerset, NJ, USA
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Article Information

vol. 69 no. 1 88-95
DOI 
https://doi.org/10.5731/pdajpst.2015.01009
PubMed 
25691717

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online February 17, 2015.

Copyright & Usage 
© PDA, Inc. 2015

Author Information

  1. Koji Nakamura1,*,
  2. Yoshihiko Abe1,
  3. Hideaki Kiminami1,
  4. Arisa Yamashita1,
  5. Kazuhiro Iwasaki1,
  6. Shigeru Suzuki1,
  7. Keisuke Yoshino1,
  8. William Dierick2 and
  9. Kevin Constable3
  1. 1Terumo Corporation, R&D Center, Kanagawa, Japan;
  2. 2Terumo Europe NV, Leuven, Belgium; and
  3. 3Terumo Medical Corporation, Somerset, NJ, USA
  1. ↵*Corresponding Author: Koji Nakamura, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan. Telephone: +81-465-81-4187; Fax: +81-465-81-4114; e-mail: Kouji2Nakamura@terumo.co.jp
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PDA Journal of Pharmaceutical Science and Technology: 69 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 69, Issue 1
January/February 2015
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A Strategy for the Prevention of Protein Oxidation by Drug Product in Polymer-Based Syringes
Koji Nakamura, Yoshihiko Abe, Hideaki Kiminami, Arisa Yamashita, Kazuhiro Iwasaki, Shigeru Suzuki, Keisuke Yoshino, William Dierick, Kevin Constable
PDA Journal of Pharmaceutical Science and Technology Jan 2015, 69 (1) 88-95; DOI: 10.5731/pdajpst.2015.01009
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Keywords

  • COP
  • Radicals
  • Steam sterilization
  • Autoclave
  • Protein
  • stability
  • oxidation

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A Strategy for the Prevention of Protein Oxidation by Drug Product in Polymer-Based Syringes
Koji Nakamura, Yoshihiko Abe, Hideaki Kiminami, Arisa Yamashita, Kazuhiro Iwasaki, Shigeru Suzuki, Keisuke Yoshino, William Dierick, Kevin Constable
PDA Journal of Pharmaceutical Science and Technology Jan 2015, 69 (1) 88-95; DOI: 10.5731/pdajpst.2015.01009

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