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Research ArticleResearch

Characterization of Propylene Glycol–Mitigated Freeze/Thaw Agglomeration of a Frozen Liquid nOMV Vaccine Formulation by Static Light Scattering and Micro-Flow Imaging

Christopher D. Mensch, Harrison B. Davis and Jeffrey T. Blue
PDA Journal of Pharmaceutical Science and Technology July 2015, 69 (4) 477-498; DOI: https://doi.org/10.5731/pdajpst.2015.01057
Christopher D. Mensch
Merck & Co., West Point, PA
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  • For correspondence: christopher.mensch@merck.com
Harrison B. Davis
Merck & Co., West Point, PA
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Jeffrey T. Blue
Merck & Co., West Point, PA
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PDA Journal of Pharmaceutical Science and Technology: 69 (4)
PDA Journal of Pharmaceutical Science and Technology
Vol. 69, Issue 4
July/August 2015
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Characterization of Propylene Glycol–Mitigated Freeze/Thaw Agglomeration of a Frozen Liquid nOMV Vaccine Formulation by Static Light Scattering and Micro-Flow Imaging
Christopher D. Mensch, Harrison B. Davis, Jeffrey T. Blue
PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 477-498; DOI: 10.5731/pdajpst.2015.01057

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Characterization of Propylene Glycol–Mitigated Freeze/Thaw Agglomeration of a Frozen Liquid nOMV Vaccine Formulation by Static Light Scattering and Micro-Flow Imaging
Christopher D. Mensch, Harrison B. Davis, Jeffrey T. Blue
PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 477-498; DOI: 10.5731/pdajpst.2015.01057
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Keywords

  • Vaccine
  • formulation
  • Freeze/thaw
  • Aluminum Adjuvant
  • nOMV
  • Propylene glycol
  • Particle sizing
  • Static light scattering
  • Micro-flow imaging
  • Cryo-EM
  • Agglomeration

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