Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

Ada Hui; Xanthe M. Lam; Christopher Kuehl; Ulla Grauschopf; Y. John Wang

doi:10.5731/pdajpst.2015.01059

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Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

Ada Hui, Xanthe M. Lam, Christopher Kuehl, Ulla Grauschopf and Y. John Wang

PDA Journal of Pharmaceutical Science and Technology July 2015, 69 (4) 511-525; DOI: https://doi.org/10.5731/pdajpst.2015.01059

Ada Hui

aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;

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Xanthe M. Lam

aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;

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Christopher Kuehl

bUniversity of Kansas, 1450 Jayhawk Blvd, Lawrence, KS 66045, USA;

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Ulla Grauschopf

cLate Stage Pharmaceutical and Processing Development, F. Hoffmann La-Roche Ltd, CH4070 Basel, Switzerland

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Y. John Wang

aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;

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For correspondence: wang.john@gene.com

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vol. 69 no. 4 511-525

DOI

https://doi.org/10.5731/pdajpst.2015.01059

PubMed

26242787

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online August 4, 2015.

Author Information

Ada Huia,
Xanthe M. Lama,
Christopher Kuehlb,
Ulla Grauschopfc and
Y. John Wanga,*

^aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;
^bUniversity of Kansas, 1450 Jayhawk Blvd, Lawrence, KS 66045, USA;
^cLate Stage Pharmaceutical and Processing Development, F. Hoffmann La-Roche Ltd, CH4070 Basel, Switzerland

↵*Corresponding Author: Y. John Wang, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080. Telephone: 650-467-7228; e-mail: wang.john{at}gene.com

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Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

Ada Hui, Xanthe M. Lam, Christopher Kuehl, Ulla Grauschopf, Y. John Wang

PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 511-525; DOI: 10.5731/pdajpst.2015.01059

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Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

Ada Hui, Xanthe M. Lam, Christopher Kuehl, Ulla Grauschopf, Y. John Wang

PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 511-525; DOI: 10.5731/pdajpst.2015.01059

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Keywords

monoclonal antibody
Methionine oxidation
Kinetics
Hydrogen peroxide
Spiking studies
Isolator

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