Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleResearch

Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

Ada Hui, Xanthe M. Lam, Christopher Kuehl, Ulla Grauschopf and Y. John Wang
PDA Journal of Pharmaceutical Science and Technology July 2015, 69 (4) 511-525; DOI: https://doi.org/10.5731/pdajpst.2015.01059
Ada Hui
aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xanthe M. Lam
aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Kuehl
bUniversity of Kansas, 1450 Jayhawk Blvd, Lawrence, KS 66045, USA;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulla Grauschopf
cLate Stage Pharmaceutical and Processing Development, F. Hoffmann La-Roche Ltd, CH4070 Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Y. John Wang
aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: wang.john@gene.com
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 69 no. 4 511-525
DOI 
https://doi.org/10.5731/pdajpst.2015.01059
PubMed 
26242787

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online August 4, 2015.

Copyright & Usage 
© PDA, Inc. 2015

Author Information

  1. Ada Huia,
  2. Xanthe M. Lama,
  3. Christopher Kuehlb,
  4. Ulla Grauschopfc and
  5. Y. John Wanga,*
  1. aLate Stage Pharmaceutical Development, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080, USA;
  2. bUniversity of Kansas, 1450 Jayhawk Blvd, Lawrence, KS 66045, USA;
  3. cLate Stage Pharmaceutical and Processing Development, F. Hoffmann La-Roche Ltd, CH4070 Basel, Switzerland
  1. ↵*Corresponding Author: Y. John Wang, Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080. Telephone: 650-467-7228; e-mail: wang.john{at}gene.com
View Full Text

Cited By...

  • Citations
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 69 (4)
PDA Journal of Pharmaceutical Science and Technology
Vol. 69, Issue 4
July/August 2015
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 9 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies
Ada Hui, Xanthe M. Lam, Christopher Kuehl, Ulla Grauschopf, Y. John Wang
PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 511-525; DOI: 10.5731/pdajpst.2015.01059

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies
Ada Hui, Xanthe M. Lam, Christopher Kuehl, Ulla Grauschopf, Y. John Wang
PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 511-525; DOI: 10.5731/pdajpst.2015.01059
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials
    • Methods
    • Results and Discussion
    • Conclusion
    • Acknowledgments
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Development and Validation of a Customized Amplex UltraRed Assay for Sensitive Hydrogen Peroxide Detection in Pharmaceutical Water
  • Vapor-Phase Hydrogen Peroxide Uptake by Silicone Tubing and Primary Packaging Components during Protein Drug Product Aseptic Filling: Impact of Pretreatment and Sterilization Process
  • Vapor Phase Hydrogen Peroxide Decontamination or Sanitization of an Isolator for Aseptic Filling of Monoclonal Antibody Drug Product--Hydrogen Peroxide Uptake and Impact on Protein Quality
  • Google Scholar

More in this TOC Section

  • Quantitative and Qualitative Evaluation of Microorganism Profile Identified in Bioburden Analysis in a Biopharmaceutical Facility in Brazil: Criteria for Classification and Management of Results
  • Evaluation of Extreme Depyrogenation Conditions on the Surface Hydrolytic Resistance of Glass Containers for Pharmaceutical Use
  • A Holistic Approach for Filling Volume Variability Evaluation and Control with Statistical Tool
Show more Research

Similar Articles

Keywords

  • monoclonal antibody
  • Methionine oxidation
  • Kinetics
  • Hydrogen peroxide
  • Spiking studies
  • Isolator

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire