Characterization of Protein Aggregating Tungstates: Electrospray Mass Spectrometry Analysis of Extracts from Prefilled Syringes and from Tungsten Pins Used in the Manufacture of Syringes

Michael Ronk; Hans Lee; Kiyoshi Fujimori; Ping Yeh; Yasser Nashed-Samuel

doi:10.5731/pdajpst.2015.005546

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Characterization of Protein Aggregating Tungstates: Electrospray Mass Spectrometry Analysis of Extracts from Prefilled Syringes and from Tungsten Pins Used in the Manufacture of Syringes

Michael Ronk, Hans Lee, Kiyoshi Fujimori, Ping Yeh and Yasser Nashed-Samuel

PDA Journal of Pharmaceutical Science and Technology January 2016, 70 (1) 51-61; DOI: https://doi.org/10.5731/pdajpst.2015.005546

Michael Ronk

1Materials and Systems Analytics, Amgen Inc., Thousand Oaks, CA; and

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For correspondence: mronk@amgen.com

Hans Lee

1Materials and Systems Analytics, Amgen Inc., Thousand Oaks, CA; and

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Kiyoshi Fujimori

1Materials and Systems Analytics, Amgen Inc., Thousand Oaks, CA; and

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Ping Yeh

2Drug Product Formulation Technologies, Amgen Inc., Thousand Oaks CA, 91320

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Yasser Nashed-Samuel

1Materials and Systems Analytics, Amgen Inc., Thousand Oaks, CA; and

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vol. 70 no. 1 51-61

DOI

https://doi.org/10.5731/pdajpst.2015.005546

PubMed

26797967

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online February 16, 2016.

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previous version (January 21, 2016 - 17:53).
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Michael Ronk1,*,
Hans Lee1,
Kiyoshi Fujimori1,
Ping Yeh2 and
Yasser Nashed-Samuel1

¹Materials and Systems Analytics, Amgen Inc., Thousand Oaks, CA; and
²Drug Product Formulation Technologies, Amgen Inc., Thousand Oaks CA, 91320

↵* Corresponding Author: Michael Ronk, One Amgen Center Drive, Amgen Inc., Thousand Oaks, CA 91320; Telephone (805)447-1352; e-mail: mronk{at}amgen.com

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Characterization of Protein Aggregating Tungstates: Electrospray Mass Spectrometry Analysis of Extracts from Prefilled Syringes and from Tungsten Pins Used in the Manufacture of Syringes

Michael Ronk, Hans Lee, Kiyoshi Fujimori, Ping Yeh, Yasser Nashed-Samuel

PDA Journal of Pharmaceutical Science and Technology Jan 2016, 70 (1) 51-61; DOI: 10.5731/pdajpst.2015.005546

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Characterization of Protein Aggregating Tungstates: Electrospray Mass Spectrometry Analysis of Extracts from Prefilled Syringes and from Tungsten Pins Used in the Manufacture of Syringes

Michael Ronk, Hans Lee, Kiyoshi Fujimori, Ping Yeh, Yasser Nashed-Samuel

PDA Journal of Pharmaceutical Science and Technology Jan 2016, 70 (1) 51-61; DOI: 10.5731/pdajpst.2015.005546

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Keywords

Syringe Extracts
Tungsten
Tungstate
protein aggregation
Tungsten Pins
Mass spectrometry

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