Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms That Affect Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu; Dax Lamar; Oliver B. Stauch; Yuh-Fun Maa

doi:10.5731/pdajpst.2015.005926

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Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms That Affect Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu, Dax Lamar, Oliver B. Stauch and Yuh-Fun Maa

PDA Journal of Pharmaceutical Science and Technology March 2016, 70 (2) 143-156; DOI: https://doi.org/10.5731/pdajpst.2015.005926

Wendy Shieu

Pharmaceutical Processing and Technology Development, Genentech, a member of the Roche Group, South San Francisco, CA

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Dax Lamar

Pharmaceutical Processing and Technology Development, Genentech, a member of the Roche Group, South San Francisco, CA

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Oliver B. Stauch

Pharmaceutical Processing and Technology Development, Genentech, a member of the Roche Group, South San Francisco, CA

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Yuh-Fun Maa

Pharmaceutical Processing and Technology Development, Genentech, a member of the Roche Group, South San Francisco, CA

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For correspondence: maay@gene.com

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vol. 70 no. 2 143-156

DOI

https://doi.org/10.5731/pdajpst.2015.005926

PubMed

26797970

Published By

Parenteral Drug Association (PDA)

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1079-7440

Online ISSN

1948-2124

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Published online April 13, 2016.

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previous version (January 21, 2016 - 17:53).
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Wendy Shieu,
Dax Lamar,
Oliver B. Stauch and
Yuh-Fun Maa*

Pharmaceutical Processing and Technology Development, Genentech, a member of the Roche Group, South San Francisco, CA

↵* Corresponding Author: Yuh-Fun Maa, Genentech, a member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080. Telephone: 650-225-3499; Fax: 650-742-1504; e-mail: maay{at}gene.com

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Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms That Affect Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu, Dax Lamar, Oliver B. Stauch, Yuh-Fun Maa

PDA Journal of Pharmaceutical Science and Technology Mar 2016, 70 (2) 143-156; DOI: 10.5731/pdajpst.2015.005926

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Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms That Affect Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu, Dax Lamar, Oliver B. Stauch, Yuh-Fun Maa

PDA Journal of Pharmaceutical Science and Technology Mar 2016, 70 (2) 143-156; DOI: 10.5731/pdajpst.2015.005926

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Keywords

Peristaltic pump
High-concentration monoclonal antibody
Fill weight precision
Suck-back
Liquid/nozzle interactions

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