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Research ArticleResearch

New Processes for Freeze-Drying in Dual-Chamber Systems

T. Werk, I. S. Ludwig, J. Luemkemann, J. Huwyler, H.-C. Mahler, C. R. Haeuser and M. Hafner
PDA Journal of Pharmaceutical Science and Technology May 2016, 70 (3) 191-207; DOI: https://doi.org/10.5731/pdajpst.2015.006155
T. Werk
1Pharmaceutical Technology, University of Basel, Basel, Switzerland;
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland; currently at Lonza AG, Drug Product Services, Basel, Switzerland; and
3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim (Germany)
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  • For correspondence: tobias.werk@roche.com
I. S. Ludwig
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland; currently at Lonza AG, Drug Product Services, Basel, Switzerland; and
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J. Luemkemann
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland; currently at Lonza AG, Drug Product Services, Basel, Switzerland; and
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J. Huwyler
1Pharmaceutical Technology, University of Basel, Basel, Switzerland;
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H.-C. Mahler
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland; currently at Lonza AG, Drug Product Services, Basel, Switzerland; and
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C. R. Haeuser
1Pharmaceutical Technology, University of Basel, Basel, Switzerland;
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland; currently at Lonza AG, Drug Product Services, Basel, Switzerland; and
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M. Hafner
3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim (Germany)
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  • Article
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References

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PDA Journal of Pharmaceutical Science and Technology: 70 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 70, Issue 3
May/June 2016
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New Processes for Freeze-Drying in Dual-Chamber Systems
T. Werk, I. S. Ludwig, J. Luemkemann, J. Huwyler, H.-C. Mahler, C. R. Haeuser, M. Hafner
PDA Journal of Pharmaceutical Science and Technology May 2016, 70 (3) 191-207; DOI: 10.5731/pdajpst.2015.006155

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New Processes for Freeze-Drying in Dual-Chamber Systems
T. Werk, I. S. Ludwig, J. Luemkemann, J. Huwyler, H.-C. Mahler, C. R. Haeuser, M. Hafner
PDA Journal of Pharmaceutical Science and Technology May 2016, 70 (3) 191-207; DOI: 10.5731/pdajpst.2015.006155
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Keywords

  • Freeze-drying
  • dual-chamber syringe
  • dual-chamber system
  • Aseptic processing
  • Biologics
  • Biopharmaceutical
  • Small-volume parenterals

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