Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleTechnology/Application

Validation of a Spectral Method for Quantitative Measurement of Color in Protein Drug Solutions

Jian Yin, Trevor E. Swartz, Jian Zhang, Thomas W. Patapoff, Bartolo Chen, Joseph Marhoul, Norman Shih, Bruce Kabakoff and Kimia Rahimi
PDA Journal of Pharmaceutical Science and Technology July 2016, 70 (4) 382-391; DOI: https://doi.org/10.5731/pdajpst.2016.006494
Jian Yin
1Early Stage Pharmaceutical Development Department,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Yin.Jian@gene.com
Trevor E. Swartz
1Early Stage Pharmaceutical Development Department,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jian Zhang
2Analytical Development and Quality Control Department, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas W. Patapoff
1Early Stage Pharmaceutical Development Department,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bartolo Chen
2Analytical Development and Quality Control Department, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Marhoul
3Nonclinical Biostatistics, Genentech, Inc., South San Francisco, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Norman Shih
1Early Stage Pharmaceutical Development Department,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruce Kabakoff
1Early Stage Pharmaceutical Development Department,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kimia Rahimi
2Analytical Development and Quality Control Department, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 70 no. 4 382-391
DOI 
https://doi.org/10.5731/pdajpst.2016.006494
PubMed 
27091890

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online July 18, 2016.

Article Versions

  • previous version (April 18, 2016 - 18:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2016

Author Information

  1. Jian Yin1,*,
  2. Trevor E. Swartz1,
  3. Jian Zhang2,
  4. Thomas W. Patapoff1,
  5. Bartolo Chen2,
  6. Joseph Marhoul3,
  7. Norman Shih1,
  8. Bruce Kabakoff1 and
  9. Kimia Rahimi2
  1. 1Early Stage Pharmaceutical Development Department,
  2. 2Analytical Development and Quality Control Department, and
  3. 3Nonclinical Biostatistics, Genentech, Inc., South San Francisco, CA
  1. ↵* Corresponding Author: Jian Yin, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; Telephone: (650) 225-2163; e-mail: Yin.Jian{at}gene.com
View Full Text

Cited By...

  • 4 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Mechanisms of color formation in drug substance and mitigation strategies for the manufacture and storage of therapeutic proteins produced using mammalian cell culture
    Cheng Du, Jianlin Xu, Hangtian Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Michael C. Borys, Zheng Jian Li
    Process Biochemistry 2019 86
  • Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury
    Genglong Liu, Haijin Lv, Yuling An, Xuxia Wei, Xiaomeng Yi, Huimin Yi
    International Journal of Molecular Medicine 2018
  • The Different Colors of mAbs in Solution
    Alexandre Ambrogelly
    Antibodies 2021 10 2
  • Advances in the use of instrumental measurement of colour in the development, production and quality control of drugs, medicinal preparations and pharmaceutical auxiliary substances III
    Jan Šubert, Jozef Čižmárik, Jozef Kolář
    Česká a slovenská farmacie 2020 69 2
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 70 (4)
PDA Journal of Pharmaceutical Science and Technology
Vol. 70, Issue 4
July/August 2016
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Validation of a Spectral Method for Quantitative Measurement of Color in Protein Drug Solutions
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 15 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Validation of a Spectral Method for Quantitative Measurement of Color in Protein Drug Solutions
Jian Yin, Trevor E. Swartz, Jian Zhang, Thomas W. Patapoff, Bartolo Chen, Joseph Marhoul, Norman Shih, Bruce Kabakoff, Kimia Rahimi
PDA Journal of Pharmaceutical Science and Technology Jul 2016, 70 (4) 382-391; DOI: 10.5731/pdajpst.2016.006494

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Validation of a Spectral Method for Quantitative Measurement of Color in Protein Drug Solutions
Jian Yin, Trevor E. Swartz, Jian Zhang, Thomas W. Patapoff, Bartolo Chen, Joseph Marhoul, Norman Shih, Bruce Kabakoff, Kimia Rahimi
PDA Journal of Pharmaceutical Science and Technology Jul 2016, 70 (4) 382-391; DOI: 10.5731/pdajpst.2016.006494
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results and Discussion
    • Conclusions
    • Conflict of Interest Declaration
    • Acknowledgments
    • Appendix
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Compendial Methods: Suitability Verification, Challenges and Recommendations for Proteins
  • A Spectral Method for Color Quantitation of a Protein Drug Solution
  • Google Scholar

More in this TOC Section

  • Mechanical Container Closure Integrity Test: A Method for Cartridge Systems
  • A Container Closure Integrity Test Method for Vials Stored at Cryogenic Conditions Using Headspace Oxygen Analysis
  • Best Practices for Microbial Challenge In-Use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations
Show more Technology/Application

Similar Articles

Keywords

  • spectral method
  • color
  • CIE L*a*b* values
  • suitability
  • Precision
  • Accuracy
  • Repeatability

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire