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Research ArticleConference Proceeding

Session 3.1: Protein A, Hydroxyapatite, and Mixed-Mode Chromatography

Dayue Chen
PDA Journal of Pharmaceutical Science and Technology September 2016, 70 (5) 443-450; DOI: https://doi.org/10.5731/pdajpst.2016.006932
Dayue Chen
Bioprocess Research & Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285; (317) 433-7629;
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  • For correspondence: CHEN_DAYUE@LILLY.COM
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References

  1. 1.↵
    1. Hubbard B.,
    2. Roush D.
    Emerging Unit operations (Session III): Hydroxyapatite, Mixed-Mode, and Adsorptive Membrane Chromatography; UV-C Inactivation; Chemical Precipitation. PDA J. Pharm. Sci. Technol. 2014, 68 (1), 51–65.
    OpenUrlFREE Full Text
  2. 2.↵
    1. Hubbard B.
    Session 1.5: Other Viral Clearance and Inactivation Approaches (Multimodal Chromatography, Membrane Chromatography, Chemical Precipitation). PDA J. Pharm. Sci. Technol. 2015, 69 (1), 173–182.
    OpenUrlFREE Full Text
  3. 3.↵
    1. Connell-Crowley L.,
    2. Larimore E. A.,
    3. Gillespie R.
    Using High Throughput Screening To Define Virus Clearance by Chromatography Resins. Biotechnol. Bioeng. 2013, 110 (7), 1984–1994.
    OpenUrl
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PDA Journal of Pharmaceutical Science and Technology: 70 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 70, Issue 5
September/October 2016
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Session 3.1: Protein A, Hydroxyapatite, and Mixed-Mode Chromatography
Dayue Chen
PDA Journal of Pharmaceutical Science and Technology Sep 2016, 70 (5) 443-450; DOI: 10.5731/pdajpst.2016.006932

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Session 3.1: Protein A, Hydroxyapatite, and Mixed-Mode Chromatography
Dayue Chen
PDA Journal of Pharmaceutical Science and Technology Sep 2016, 70 (5) 443-450; DOI: 10.5731/pdajpst.2016.006932
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  • Article
    • Introduction
    • 3.1.1. Viral Clearance of the Capto Adhere Chromatography Step In Monoclonal Antibody (mAb) Purification Processes (Junfen Ma; Pivotal Purification Process Development Amgen Inc., Cambridge, MA)
    • 3.1.2. Clearance of XMuLV and Minute Virus of Mice (MVM) by Ceramic Hydroxyapatite (HAP), Mixed-Mode and Anion Exchange (AEX) Chromatography for Pharmaceutical Antibodies with Low pI (Seiryu Ujiie; Chugai Pharmaceutical Co., Ltd, Tokyo, Japan)
    • 3.1.3. Virus Clearance Robustness for Multimodal AEX Chromatography (Sherrie Curtis; Genentech Inc., South San Francisco, CA)
    • 3.1.4. Evaluation of the Viral Clearance Capacity and Robustness of the Manufacturing Process for the Recombinant Factor VIII (rFVII) Protein, Turoctocog Alfa (Søren Kamstrup; NovoNordisk A/S, Gentofte, Denmark)
    • 3.1.5. Evaluation of Agarose-Based Protein A Chromatography as a Reliable Virus Removal Step: Modeling and Outlier Analysis (John Ruppino and John Mattila; Regeneron, Tarrytown, NY)
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Cited By...

  • Proceedings of the 2019 Viral Clearance Symposium, Session 2: New Modalities in Chromatography and Adsorptive Filters
  • Proceedings of the 2017 Viral Clearance Symposium, Session 2.2: DSP Unit Operations-Purification Unit Operations
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  • Proceedings of the 2017 Viral Clearance Symposium, Session 2.2: DSP Unit Operations–Purification Unit Operations
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  • Proceedings of the 2017 Viral Clearance Symposium, Session 4: Submission Strategies
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