The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes

Tobias Werk; Imke S. Ludwig; Hanns-Christian Mahler; Joerg Luemkemann; Joerg Huwyler; Mathias Hafner

doi:10.5731/pdajpst.2015.006387

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The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes

Tobias Werk, Imke S. Ludwig, Hanns-Christian Mahler, Joerg Luemkemann, Joerg Huwyler and Mathias Hafner

PDA Journal of Pharmaceutical Science and Technology November 2016, 70 (6) 508-522; DOI: https://doi.org/10.5731/pdajpst.2015.006387

Tobias Werk

1Pharmaceutical Technology, University of Basel, Basel, Switzerland;

2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland;

3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany; and

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For correspondence: tobias.werk@roche.com

Imke S. Ludwig

2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland;

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Hanns-Christian Mahler

4current address: Lonza AG, Drug Product Services, Basel, Switzerland

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Joerg Luemkemann

2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland;

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Joerg Huwyler

1Pharmaceutical Technology, University of Basel, Basel, Switzerland;

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Mathias Hafner

3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany; and

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vol. 70 no. 6 508-522

DOI

https://doi.org/10.5731/pdajpst.2015.006387

PubMed

27974591

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online December 13, 2016.

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previous version (June 20, 2016 - 13:19).
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Author Information

Tobias Werk1,2,3,*,
Imke S. Ludwig2,
Hanns-Christian Mahler4,
Joerg Luemkemann2,
Joerg Huwyler1 and
Mathias Hafner3

¹Pharmaceutical Technology, University of Basel, Basel, Switzerland;
²Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel, Switzerland;
³Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany; and
⁴current address: Lonza AG, Drug Product Services, Basel, Switzerland

↵* Corresponding Author: F. Hoffmann-La Roche Ltd., Pharmaceutical Development & Supplies (PTDE-P), Bldg 64/443, Grenzacherstrasse 124, CH-4070 Basel, Switzerland. Telephone: +41 61 688 5417; e-mail: tobias.werk{at}roche.com

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The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes

Tobias Werk, Imke S. Ludwig, Hanns-Christian Mahler, Joerg Luemkemann, Joerg Huwyler, Mathias Hafner

PDA Journal of Pharmaceutical Science and Technology Nov 2016, 70 (6) 508-522; DOI: 10.5731/pdajpst.2015.006387

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The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes

Tobias Werk, Imke S. Ludwig, Hanns-Christian Mahler, Joerg Luemkemann, Joerg Huwyler, Mathias Hafner

PDA Journal of Pharmaceutical Science and Technology Nov 2016, 70 (6) 508-522; DOI: 10.5731/pdajpst.2015.006387

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