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Research ArticleResearch

Impact of Drug Formulation Variables on Silicone Oil Structure and Functionality of Prefilled Syringe System

Galen H. Shi, Ganapathy Gopalrathnam, Sharon L. Shinkle, Xia Dong, Jeffrey D. Hofer, Eric C. Jensen and Natarajan Rajagopalan
PDA Journal of Pharmaceutical Science and Technology January 2018, 72 (1) 50-61; DOI: https://doi.org/10.5731/pdajpst.2017.008169
Galen H. Shi
2Delivery Device and Connected Solutions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
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Ganapathy Gopalrathnam
1Bioproduct Pharma Design, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
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Sharon L. Shinkle
1Bioproduct Pharma Design, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
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Xia Dong
4Biotechnolgy Research (Bio TDR), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
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Jeffrey D. Hofer
3Statistics - Discovery and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN; and
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Eric C. Jensen
2Delivery Device and Connected Solutions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
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Natarajan Rajagopalan
1Bioproduct Pharma Design, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
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  • For correspondence: rajagopalan.natarajan@lilly.com
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Article Information

vol. 72 no. 1 50-61
DOI 
https://doi.org/10.5731/pdajpst.2017.008169
PubMed 
29030531

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online January 30, 2018.

Article Versions

  • previous version (October 12, 2017 - 19:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2018

Author Information

  1. Galen H. Shi2,
  2. Ganapathy Gopalrathnam1,
  3. Sharon L. Shinkle1,
  4. Xia Dong4,
  5. Jeffrey D. Hofer3,
  6. Eric C. Jensen2 and
  7. Natarajan Rajagopalan1,*
  1. 1Bioproduct Pharma Design, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
  2. 2Delivery Device and Connected Solutions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN;
  3. 3Statistics - Discovery and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN; and
  4. 4Biotechnolgy Research (Bio TDR), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
  1. ↵*Corresponding Author: Telephone: 317-276-4023; e-mail: rajagopalan.natarajan{at}lilly.com
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PDA Journal of Pharmaceutical Science and Technology: 72 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 72, Issue 1
January/February 2018
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Impact of Drug Formulation Variables on Silicone Oil Structure and Functionality of Prefilled Syringe System
Galen H. Shi, Ganapathy Gopalrathnam, Sharon L. Shinkle, Xia Dong, Jeffrey D. Hofer, Eric C. Jensen, Natarajan Rajagopalan
PDA Journal of Pharmaceutical Science and Technology Jan 2018, 72 (1) 50-61; DOI: 10.5731/pdajpst.2017.008169

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Impact of Drug Formulation Variables on Silicone Oil Structure and Functionality of Prefilled Syringe System
Galen H. Shi, Ganapathy Gopalrathnam, Sharon L. Shinkle, Xia Dong, Jeffrey D. Hofer, Eric C. Jensen, Natarajan Rajagopalan
PDA Journal of Pharmaceutical Science and Technology Jan 2018, 72 (1) 50-61; DOI: 10.5731/pdajpst.2017.008169
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Keywords

  • Formulation development
  • Buffer
  • Semi-finished
  • prefilled syringe
  • functionality
  • Break loose force
  • Glide force
  • Schlieren imaging
  • Contact angle
  • Monoclonal antibodies
  • Silicone oil
  • Inductively coupled plasma emission spectroscopy
  • Thin film interference reflectometry

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