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Research ArticleProceedings of the 2017 Viral Clearance Symposium

Proceedings of the 2017 Viral Clearance Symposium, Session 1.2: Upstream Mitigation, Part 2—Virus Barrier Filter and HTST

Dayue Chen and Glen Bolton
PDA Journal of Pharmaceutical Science and Technology September 2018, 72 (5) 462-469; DOI: https://doi.org/10.5731/pdajpst.2018.009100
Dayue Chen
1Eli Lilly, Bioprocess Research & Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA; and
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  • For correspondence: CHEN_DAYUE@LILLY.COM
Glen Bolton
2Amgen, 360 Binney Street, Cambridge, MA 02142, USA
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Article Information

vol. 72 no. 5 462-469
DOI 
https://doi.org/10.5731/pdajpst.2018.009100
PubMed 
30030355

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online October 6, 2018.

Article Versions

  • previous version (July 20, 2018 - 14:19).
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Copyright & Usage 
© PDA, Inc. 2018

Author Information

  1. Dayue Chen1,* and
  2. Glen Bolton2
  1. 1Eli Lilly, Bioprocess Research & Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA; and
  2. 2Amgen, 360 Binney Street, Cambridge, MA 02142, USA
  1. ↵* Corresponding Author: Eli Lilly, Bioprocess Research & Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285; e-mail: CHEN_DAYUE@LILLY.COM
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In This Issue

PDA Journal of Pharmaceutical Science and Technology: 72 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 72, Issue 5
September/October 2018
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Proceedings of the 2017 Viral Clearance Symposium, Session 1.2: Upstream Mitigation, Part 2—Virus Barrier Filter and HTST
Dayue Chen, Glen Bolton
PDA Journal of Pharmaceutical Science and Technology Sep 2018, 72 (5) 462-469; DOI: 10.5731/pdajpst.2018.009100
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  • Article
    • Abstract
    • Session Overview and Background
    • News on Virus Filtration as Upstream Barrier
    • Andreas Wieser and Thomas R. Kreil, Global Pathogen Safety
    • Exploration of Viral Filtration for Two Decades
    • Shengjiang Shawn Liu, Pathogen Safety of Biological Development, Bayer Pharmaceuticals
    • Demonstration of Viral Clearance for Viral Filtration of Media
    • Glen Bolton, Scientific Director, Amgen
    • Risk Analysis for Implementation of Media Virus Barrier Filter
    • Eva Gefroh and Fernando Garcia, Just Biotherapeutics
    • Effect of Media Concentrates on Virus Barrier Filter Sizing
    • Eva Gefroh, Megan McClure, and Rebecca McCoy, Just Biotherapeutics
    • Summary
    • Conflict of Interest Declaration
    • Reference
  • Figures & Data
  • References
  • Info & Metrics
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More in this TOC Section

Proceedings of the 2017 Viral Clearance Symposium

  • Proceedings of the 2017 Viral Clearance Symposium, Session 4: Submission Strategies
  • Proceedings of the 2017 Viral Clearance Symposium: Conclusion
Show more Proceedings of the 2017 Viral Clearance Symposium

Conference Proceeding

  • Proceedings of the 2017 Viral Clearance Symposium, Session 3: Resin Lifetime
  • Proceedings of the 2017 Viral Clearance Symposium, Session 1.1: Upstream Mitigation, Part 1—Cell Bank and Bulk Harvest Testing
  • Proceedings of the 2017 Viral Clearance Symposium, Session 6: Ensuring Viral Safety in Continuous Processing
Show more Conference Proceeding

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Keywords

  • Upstream processing
  • Mammalian cell line
  • Virus barrier filtration
  • High-temperature short-time treatment
  • Viral contamination risk

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Proceedings of the 2017 Viral Clearance Symposium, Session 1.2: Upstream Mitigation, Part 2—Virus Barrier Filter and HTST
Dayue Chen, Glen Bolton
PDA Journal of Pharmaceutical Science and Technology Sep 2018, 72 (5) 462-469; DOI: 10.5731/pdajpst.2018.009100

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