Research ArticleProceedings of the 2017 Viral Clearance Symposium
Proceedings of the 2017 Viral Clearance Symposium, Session 2.1: DSP Unit Operations—Virus Filtration/Inactivation
Thomas R. Kreil and David Roush
PDA Journal of Pharmaceutical Science and Technology September 2018, 72 (5) 470-478; DOI: https://doi.org/10.5731/pdajpst.2018.009118
Thomas R. Kreil
1Department of Virology, Global Pathogen Safety, Shire; A-1220 Vienna, Austria; and
David Roush
2Bioprocess Development/Biologics Research, MSD, Kenilworth, NJ, USA
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In This Issue
PDA Journal of Pharmaceutical Science and Technology
Vol. 72, Issue 5
September/October 2018
Proceedings of the 2017 Viral Clearance Symposium, Session 2.1: DSP Unit Operations—Virus Filtration/Inactivation
Thomas R. Kreil, David Roush
PDA Journal of Pharmaceutical Science and Technology Sep 2018, 72 (5) 470-478; DOI: 10.5731/pdajpst.2018.009118
Jump to section
- Article
- Abstract
- Introduction
- Optimization of Viral Filtration Process Conditions to Enable a Representative Scale-Down Model
- Virus Filtration—challenges for Scale-Down
- Effects of Pressure Source on Virus Breakthrough During Viral Filtration
- Multiple, Deliberate Interruptions of a Virus Removal Filtration Process—Impact on Virus Retention and Throughput
- Validating an Alternative Virus Reduction Filter for a Commercial Product
- Investigational Study on the Robustness of the 20-nm Nanofiltration Step Performed According to the Doe Methodology
- What to Do When the Virus Filtration Cannot Be Validated as Usual?
- Establishing a Generic Claim for Lauryldimethylamine N-oxide Detergent Inactivation
- Virus Inactivation at Low pH: Impact of Buffer Composition, pH Value, and Protein Concentration on the Inactivation of Different Retroviruses
- Conclusion
- Conflict of Interest Declaration
- Reference
- Figures & Data
- References
- Info & Metrics
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