Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation

Alejandra Nieto; Holger Roehl; Michael Adler; Silke Mohl

doi:10.5731/pdajpst.2017.008383

Research ArticleResearch

Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation

Alejandra Nieto, Holger Roehl, Michael Adler and Silke Mohl

PDA Journal of Pharmaceutical Science and Technology November 2018, 72 (6) 544-552; DOI: https://doi.org/10.5731/pdajpst.2017.008383

Alejandra Nieto

Pharmaceutical Development & Supplies—PTD Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: alejandra.nieto-pena@roche.com

Holger Roehl

Pharmaceutical Development & Supplies—PTD Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael Adler

Pharmaceutical Development & Supplies—PTD Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Silke Mohl

Pharmaceutical Development & Supplies—PTD Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
References
Info & Metrics
PDF

Article Information

vol. 72 no. 6 544-552

DOI

https://doi.org/10.5731/pdajpst.2017.008383

PubMed

29853608

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online December 4, 2018.

Article Versions

previous version (May 31, 2018 - 12:56).
You are viewing the most recent version of this article.

Author Information

Alejandra Nieto*,
Holger Roehl,
Michael Adler and
Silke Mohl

Pharmaceutical Development & Supplies—PTD Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

↵*Corresponding Author: F. Hoffmann-La Roche Ltd., Pharmaceutical Development & Supplies—PTD Biologics Europe, Grenzacherstrasse 124, CH-4070 Basel, Switzerland; e-mail: alejandra.nieto-pena{at}roche.com

View Full Text

Cited By...

Citations
Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

PreviousNext

In This Issue

PDA Journal of Pharmaceutical Science and Technology

Vol. 72, Issue 6

November/December 2018

Table of Contents
Index by Author

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation

Message Subject (Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology

Message Body (Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Math question * 1 + 1 =

Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Citation Tools

Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation

Alejandra Nieto, Holger Roehl, Michael Adler, Silke Mohl

PDA Journal of Pharmaceutical Science and Technology Nov 2018, 72 (6) 544-552; DOI: 10.5731/pdajpst.2017.008383

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation

Alejandra Nieto, Holger Roehl, Michael Adler, Silke Mohl

PDA Journal of Pharmaceutical Science and Technology Nov 2018, 72 (6) 544-552; DOI: 10.5731/pdajpst.2017.008383

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Jump to section

Article
Figures & Data
Info & Metrics
References
PDF

No related articles found.

PubMed
Google Scholar

Cited By...

Quantifying the Vial-Capping Process: Reexamination Using Micro-Computed Tomography
Sealing Behaviour of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers

Google Scholar

Keywords

Container closure integrity
Frozen drug product
Vial
Helium-leakage test
headspace analysis
Transportation
Capping
Residual seal force

Main menu

User menu

Search

Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation

Article Information

Article Versions

Author Information

Cited By...

In This Issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Keywords

Readers

Author/Reviewer Information

Parenteral Drug Association, Inc.